Printable and flexible graphene pH sensors utilising thin film melanin for physiological applications
Source abstract
Abstract
Abstract The application of highly sensitive pH sensors manufactured in volume at low cost has great commercial interest due to an extensive array of potential applications. Such areas include industrial processing, biotechnology and medical diagnostics particularly in the development of point of care (POC) devices. A novel printable electrochemical pH sensor based on graphene and pigment melanin (PGM), was designed and produced by using a screen printing process that enables up scaling for potential commercial application. We demonstrate a highly sensitive pH sensor (62 mV pH−1 ± 7) over a pH range from 5 to 8, with high stability and superior performance when compared with a number of existing devices and making it suitable for physiological applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Analytical Chemistry and Sensors · Conducting polymers and applications · Electrochemical sensors and biosensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (72)
Show source-provided references
1. Recent advances in lactic acid production by microbial fermentation processes10.1016/j.biotechadv.2013.04.002 ↗
2. Bandage-based wearable potentiometric sensor for monitoring wound pH10.1002/elan.201300558 ↗
3. Soil calcium and pH monitoring sensor system10.1021/jf063746a ↗
4. Modulation of culture medium confers high-specificity production of isopentenol in Bacillus subtilis10.1016/j.jbiosc.2018.10.002 ↗
5. Digital pH test strips for in-field pH monitoring using iridium oxide-reduced graphene oxide hybrid thin films10.1021/acssensors.6b00385 ↗
6. New technology for the detection of pH10.1016/j.jbbm.2005.02.001 ↗
7. The glass electrode—applied electrochemistry of glass surfaces10.1016/0022-3093(85)90348-5 ↗
8. Bioelectrochemical determination of lactic and malic acids in wine10.1016/0039-9140(94)E0044-R ↗
9. Potentiometric microsensors10.1021/cr00103a001 ↗
10. Potentiometric biosensor for urea based on electropolymerized electroinactive polypyrrole10.1016/S0013-4686(96)00226-5 ↗
11. Conducting polymer-based biosensors10.1016/0013-4686(94)E0054-4 ↗
12. Simple absorption optical fiber pH sensor based on doped sol-gel cladding material10.1021/cm9703334 ↗
13. Screen-printable sol–gel ceramic carbon composite pH sensor with a receptor zeolite10.1016/S0003-2670(01)01540-9 ↗
14. A flexible pH sensor based on the iridium oxide sensing film10.1016/j.sna.2011.05.016 ↗
15. Structural properties and sensing performance of high-k Sm2O3 membrane-based electrolyte–insulator–semiconductor for pH and urea detection10.1016/j.snb.2009.01.059 ↗
16. A low-cost flexible pH sensor array for wound assessment10.1016/j.snb.2015.12.082 ↗
17. Sensing mechanism of RuO2–SnO2 thick film pH sensors studied by potentiometric method and electrochemical impedance spectroscopy10.1016/j.jelechem.2015.10.036 ↗
18. A graphene oxide pH sensor for wound monitoring10.1109/EMBC.2016.7591092 ↗
19. Iridium oxide-reduced graphene oxide nanohybrid thin film modified screen-printed electrodes as disposable electrochemical paper microfluidic pH sensors10.3791/53339 ↗
20. Three dimensional graphene transistor for ultra-sensitive pH sensing directly in biological media10.1016/j.aca.2016.05.048 ↗
21. Temperature and pH sensors based on graphenic materials10.1016/j.bios.2017.01.062 ↗
22. Study on extended gate field effect transistor with tin oxide sensing membrane10.1016/S0254-0584(99)00184-4 ↗
23. ZnO extended-gate field-effect transistors as p H sensors10.1063/1.2084319 ↗
24. pH and procaine sensing characteristics of extended-gate field-effect transistor based on indium tin oxide glass10.1143/JJAP.44.4838 ↗
25. Nanostructured polyaniline thin films as pH sensing membranes in FET-based devices10.1016/j.snb.2011.07.054 ↗
26. A novel pH sensor of extended-gate field-effect transistors with laser-irradiated carbon-nanotube network10.1109/LED.2012.2213794 ↗
27. Melanin as an active layer in biosensors10.1063/1.4869638 ↗
28. Recent developments in the design and application of screen-printed electrochemical sensors for biomedical, environmental and industrial analyses10.1016/S0165-9936(96)00097-0 ↗
29. A disposable amperometric sensor screen printed on a nitrocellulose strip: a glucose biosensor employing lead oxide as an interference-removing agent10.1021/ac991213d ↗
30. Functionalized carbon electrodes for pH determination10.1007/s10008-008-0566-7 ↗
31. State-of-the-art graphene high-frequency electronics10.1021/nl300904k ↗
32. Utilization of graphene electrode in transparent microwell arrays for high throughput cell trapping and lysis10.1016/j.bios.2014.05.067 ↗
33. Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker10.1088/2053-1583/1/2/025004 ↗
34. Graphene: status and prospects10.1126/science.1158877 ↗
35. The physical and chemical properties of eumelanin10.1111/j.1600-0749.2006.00345.x ↗
36. Melanoma biology and new targeted therapy10.1038/nature05661 ↗
37. Melanocyte biology and skin pigmentation10.1038/nature05660 ↗
38. The neuromelanin of human substantia nigra: physiological and pathogenic aspects10.1111/j.1600-0749.2004.00201.x ↗
39. Atypical structural and pi-electron features of a melanin polymer that lead to superior free-radical-scavenging properties10.1002/anie.201305747 ↗
40. Melanins and melanogenesis: from pigment cells to human health and technological applications10.1111/pcmr.12393 ↗
41. Electronic and optoelectronic materials and devices inspired by nature10.1088/0034-4885/76/3/034501 ↗
42. Gaseous adsorption in melanins: hydrophilic biomacromolecules with high electrical conductivities10.1021/la901290f ↗
43. The structural impact of water sorption on device-quality melanin thin films10.1039/C6SM02420C ↗
44. Role of semiconductivity and ion transport in the electrical conduction of melanin10.1073/pnas.1119948109 ↗
45. Protonic and electronic transport in hydrated thin films of the pigment eumelanin10.1021/cm502939r ↗
46. Decoupling ionic and electronic currents in melanin10.1002/adfm.201805514 ↗
47. Redox chemistry in the pigment eumelanin as a function of temperature using broadband dielectric spectroscopy10.1039/C8RA09093A ↗
48. Hydration-controlled X-band EPR spectroscopy: a tool for unravelling the complexities of the solid-state free radical in eumelanin10.1021/jp401615e ↗
49. Electronic structure calculations of ESR parameters of melanin units10.1039/C4CP05256K ↗
50. The photoreactive free radical in eumelanin10.1126/sciadv.aaq1293 ↗
51. Identification of common resonant lines in the EPR spectra of melanins10.1021/acs.jpcb.8b09694 ↗
52. Current understanding of the binding sites, capacity, affinity, and biological significance of metals in melanin10.1021/jp071439h ↗
53. Chemical and structural disorder in eumelanins: a possible explanation for broadband absorbance10.1529/biophysj.105.069096 ↗
54. Towards structure–property–function relationships for eumelanin10.1039/B511922G ↗
55. Optical lens system incorporating melanin as an absorbing pigment for protection against electromagnetic radiation
56. An all-solid-state biocompatible ion-to-electron transducer for bioelectronics10.1039/C7MH00831G ↗
57. Melanin layer on silicon: an attractive structure for a possible exploitation in bio-polymer based metal-insulator-silicon devices10.1002/adma.201101358 ↗
58. Melanin-based flexible supercapacitors10.1039/C6TC03739A ↗
59. Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices10.1073/pnas.1314345110 ↗
60. A water-activated, ingestible battery
61. Poly (5, 6-dihydroxyindole) melanin film electrode10.1006/bioo.1993.1004 ↗
62. Interactions of melanin with metal ions. Electron spin resonance evidence for chelate complexes of metal ions with free radicals10.1021/ja00480a044 ↗
63. Metal binding by melanins: studies of colloidal dihydroxyindole-melanin, and its complexation by Cu(II) and Zn(II) ions10.1016/S0162-0134(01)00406-8 ↗
64. Thin films of synthetic melanin10.1016/j.jnoncrysol.2004.03.058 ↗
65. Synthesis and characterization of melanin in DMSO10.1016/j.molstruc.2013.04.061 ↗
66. Novel insights on the physicochemical properties of eumelanins and their DMSO derivatives10.1002/pi.5167 ↗
67. Structural and optical properties of soluble melanin analogues with enhanced photoluminescence quantum efficiency10.1002/pi.5543 ↗
68. Large-area printed supercapacitor technology for low-cost domestic green energy storage10.1016/j.energy.2016.11.019 ↗
69. Carbon contamination at silver surfaces: surface preparation procedures evaluated by Raman spectroscopy and x-ray photoelectron spectroscopy10.1021/ac950753h ↗
70. Resonant Raman spectroscopy of disordered, amorphous, and diamondlike carbon10.1103/PhysRevB.64.075414 ↗
71. Raman spectroscopy of graphene on different substrates and influence of defects10.1007/s12034-008-0090-5 ↗
72. Supplementing π-systems: eumelanin and graphene-like integration towards highly conductive materials for the mammalian cell culture bio-interface10.1039/C5TB00343A ↗