Engineering macromolecules self‐assembly: Molecular tubes vs. protein sheets via single amino acid substitutions in E. coli glutamine synthetase

Protein engineering provides a rationale for obtaining self‐assembling molecules which yield supramolecular arrays with varying quanternary architectures. An example is E. coli glutamine synthetase which can be manipulated to yield molecular tubes (see figure), cables, and hexagonally packed sheets magnified image.