DataVXAdvanced MaterialsPaper
journal article·2021-11

Cation‐Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy (Adv. Mater. 45/2021)

Tong Jiang, Yonghan Qiao, Weimin Ruan, Dongya Zhang, Qingshan Yang, Guoying Wang, Qunzhi Chen, Fengping Zhu, Jinlong Yin, Yan Zou, Rongjun Qian, Meng Zheng, Bingyang Shi

Advanced Materials· Volume 33· Issue 45
Publisher page
Source abstract

Abstract

Tumor Therapy In article number 2104779, Meng Zheng, Bingyang Shi, and co-workers develop a kind of polymeric siRNA micelle as an effective drug-delivery platform and potent RNAi nanomedicine for glioblastoma therapy. The siRNA micelles are capable of traversing the blood–brain barrier via transcytosis mediated by scavenger receptors, to subsequently target a brain tumor and then exert potent RNAi therapy or RNAi-Chemo synergistic therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · MicroRNA in disease regulation · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Henan Key Laboratory of Brain Targeted Bio‐Nanomedicine School of Life Sciences & School of Pharmacy Henan University Kaifeng Henan 475004 China

Henan‐Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University Kaifeng Henan 475004 China

Huaihe Hosiptal Henan University Kaifeng Henan 475004 China

Department of Biomedical Sciences Faculty of Medicine & Health Sciences Macquarie University Sydney NSW 2109 Australia

Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China

Department of Neurosurgery Henan Provincial People's Hospital Henan University People's Hospital Zhengzhou 450003 China

References

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