DataVXAdvanced MaterialsPaper
journal article·2021-07

Cells in Slow Motion: Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures (Adv. Mater. 29/2021)

Jörg Schnauß, Tom Kunschmann, Steffen Grosser, Paul Mollenkopf, Tobias Zech, Jessica S. Freitag, Dusan Prascevic, Roland Stange, Luisa S. Röttger, Susanne Rönicke, David M. Smith, Thomas M. Bayerl, Josef A. Käs

Advanced Materials· Volume 33· Issue 29
Publisher page
Source abstract

Abstract

In article number 2101840, Jörg Schnauß and co-workers show that heavy water (D2O) reversibly slows down cells, retards cell invasion, and drastically impacts cell mechanics, possibly prolonging storage times for biological materials. The cellular dynamics, which transform into slow motion, can be captured via the time-temperature superposition principle, where temperature is replaced by D2O. Induced changes are fully reversible and effects are independent of signaling/expression.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cellular Mechanics and Interactions · thermodynamics and calorimetric analyses

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Affiliations

Peter Debye Institute for Soft Matter Physics University Leipzig Linnéstraße 5 04103 Leipzig Germany

Fraunhofer Institute for Cell Therapy and Immunology Perlickstraße 1 04103 Leipzig Germany

Unconventional Computing Lab Department of Computer Science and Creative Technologies University of the West of England Bristol BS16 1QY UK

Institute of Systems Molecular and Integrative Biology University of Liverpool Crown Street Liverpool L69 7BE UK

D2 Bioscience Group Ltd Trinity Hall, 43 Cedar Ave. Hamilton HM LX Bermuda

Institute of Clinical Immunology University of Leipzig Medical Faculty 04103 Leipzig Germany

Dhirubhai Ambani Institute of Information and Communication Technology Gandhinagar 382007 India

References

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