Cancer Therapy: Harnessing the Formation of Natural Killer–Tumor Cell Immunological Synapses for Enhanced Therapeutic Effect in Solid Tumors (Adv. Mater. 22/2020)
Source abstract
Abstract
In article number 2000020, Won Jong Kim and co-workers describe a reinforced natural killer (ReNK) system, adopting the formation of NK–tumor cell immunological synapses (IS) as a trigger for delivery of tumor-specific chemotherapeutics. NK cells are decorated with the IS environment-responsive micellar system to ensure the release of drug when they attack cancer cells. The strategy enables the NK cells to inhibit the growth of solid tumors by efficient penetration of the delivered drug into the tumor tissue; otherwise, its penetration is hindered by the dense extracellular matrix of the tumor tissue.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Interdisciplinary Bioscience and Bioengineering (I‐Bio) Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea
Department of Chemistry POSTECH‐Catholic Biomedical Engineering Institute Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea
Department of Materials Science and Engineering Seoul National University Seoul 08826 Republic of Korea
GI Cell, Inc. Seoul 05855 Republic of Korea
References
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