DNA as an Electron‐Beam‐Sensitive Reagent for Nanopatterning

Gold nanoparticle patterns (see figure) produced using a DNA molecular layer as an electron-beam-sensitive reagent are reported. The authors subjected thiolated single-strand DNA to a focused electron beam, resulting in the inhibition of hybridization to complementary strands, and then used gold nanoparticles to reveal nanoscale patterns. This technique has potential applications in the fabrication of DNA-based nanostructures.