DataVXAdvanced MaterialsPaper
journal article·2019-05

Drug Delivery: A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System (Adv. Mater. 18/2019)

Di Wu, Meng Qin, Duo Xu, Lan Wang, Chaoyong Liu, Jie Ren, George Zhou, Chen Chen, Fengmei Yang, Yanyan Li, Yuan Zhao, Ruyi Huang, Sina Pourtaheri, Chunsheng Kang, Masakazu Kamata, Irvin S. Y. Chen, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu

Advanced Materials· Volume 31· Issue 18
Publisher page
Source abstract

Abstract

A universal central nervous system (CNS)-delivery platform is developed enabling the delivery of protein therapeutics to the brain via choline transporters and acetylcholine receptors. In article number 1807557, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu, and co-workers demonstrate that the protein therapeutics can effectively penetrate the blood–brain barrier in mice and nonhuman primates by encapsulating the proteins within nanocapsules with choline and acetylcholine analogues.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Biochemical and Structural Characterization · Neurological Disorders and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biomolecular Engineering University of California Los Angeles CA 90095 USA

College of Life Science and Technology Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China

Department of Microbiology Immunology and Molecular Genetics University of California Los Angeles CA 90095 USA

Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming Yunnan 650118 China

Department of Neurosurgery University of California Los Angeles CA 90095 USA

Department of Orthopedic Surgery University of California, San Diego San Diego CA 92093 USA

Tianjin Neurological Institute MOE Key Laboratory of Post‐Neuroinjury Neuro‐Repair and Regeneration in Central Nervous System The General Hospital of Tianjin Medical University Tianjin 300052 China

UCLA AIDS Institute Los Angeles CA 90095 USA

Division of Hematology–Oncology David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA

Beijing Institute of Biotechnology Beijing 100071 China

References

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