Stimuli‐Responsive Materials: Enzyme‐Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction (Adv. Mater. 37/2015)
Source abstract
Abstract
Stimuli-responsive nanoparticles, when injected systemically, circulate in the blood stream until reaching the site of myocardial infarction (MI). As reported by N. C. Gianneschi, K. L. Christman, and co-workers on page 5547, recognition by infarct-associated enzymes induces a morphology transition, triggering the subsequent aggregation of nanoparticles at the site of damage. The resulting microscale aggregates exhibit prolonged retention in the infarct, thereby providing a potential platform for delivering therapeutics to an acute MI.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bioengineering Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA 92093 USA
Department of Chemistry and Biochemistry University of California San Diego La Jolla CA 92093 USA
Department of Medicine University of California San Diego La Jolla CA 92093 USA
Animal Care Program University of California San Diego La Jolla CA 92093 USA
References
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