DataVXAdvanced MaterialsPaper
journal article·2019-05Open access

Brain Tumor Therapy: Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy (Adv. Mater. 19/2019)

Lei Han, Chaoyong Liu, Hongzhao Qi, Junhu Zhou, Jing Wen, Di Wu, Duo Xu, Meng Qin, Jie Ren, Qixue Wang, Lixia Long, Yang Liu, Irvin Chen, Xubo Yuan, Yunfeng Lu, Chunsheng Kang

Advanced Materials· Volume 31· Issue 19
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Source abstract

Abstract

In article number 1805697, Xubo Yuan, Yunfeng Lu, Chunsheng Kang, and co-workers report a platform technology that enables effective delivery of therapeutic monoclonal antibody (mAb) to the central nervous system (CNS) for brain-tumor therapy. This is achieved by encapsulating the mAbs within nanocapsules that contain choline and acetylcholine analogues. The brain takes up these mAb nanocapsuels, which facilitates the delivery of mAb across the blood–brain barrier. This platform technology uncages the therapeutic power of mAbs for various CNS diseases that remain poorly treated.
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Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · RNA Interference and Gene Delivery

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Affiliations

Department of Neurosurgery Tianjin Medical University General Hospital; Key Laboratory of Neurotrauma, Variation, and Regeneration Ministry of Education and Tianjin Municipal Government Tianjin Neurological Institute Tianjin 300052 China

College of Life Science and Technology and Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China

School of Materials Science Engineering Tianjin University Tianjin 300350 China

Department of Microbiology Immunology and Molecular Genetics David Geffen School of Medicine University of California, Los Angeles UCLA AIDS Institute Los Angeles CA 90095 USA

Department of Chemical and Biomolecular Engineering University of California Los Angeles CA 90095 USA

Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry College of Chemistry State Key Laboratory of Medicinal Chemical Biology Nankai University Tianjin 300071 China

References

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