Multidrug Resistance: In Situ shRNA Synthesis on DNA–Polylactide Nanoparticles to Treat Multidrug Resistant Breast Cancer (Adv. Mater. 10/2018)
Source abstract
Abstract
In situ rolling circle transcription (RCT) is applied by Qianqian Ni and co-workers to develop a “core–shell” microstructure. As described by Guizhi Zhu, Longjiang Zhang, Xiaoyuan Chen, and co-workers in article number 1705737, poly(short hairpin RNA) (shRNA) is synthesized on amphiphilic DNA–polylactide (PLA) nanoparticles for co-delivery of therapeutic shRNA and hydrophobic chemotherapeutics. Furthermore, polypeptide copolymer is used to shrink the microstructures into multifunctional nanoparticles.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · Nanoplatforms for cancer theranostics
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Affiliations
Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Nanjing 210002 Jiangsu China
Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) NIH Bethesda MD 20892 USA
References
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