DataVXAdvanced MaterialsPaper
journal article·2023-07Open access

Cartilage Lacuna‐Inspired Microcarriers Drive Hyaline Neocartilage Regeneration (Adv. Mater. 30/2023)

Sheng‐Long Ding, Xi‐Yuan Zhao, Wei Xiong, Lin‐Feng Ji, Min‐Xuan Jia, Yan‐Yan Liu, Hai‐Tao Guo, Feng Qu, Wenguo Cui, Qi Gu, Ming‐Zhu Zhang

Advanced Materials· Volume 35· Issue 30
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Source abstract

Abstract

Cartilage Tissue Engineering In article number 2212114, Wenguo Cui, Qi Gu, Ming-Zhu Zhang, and co-workers introduce novel cartilage lacuna-inspired microcarriers with geometric constraints to repress chondrocyte dedifferentiation by inhibiting Wnt signaling. The biomimetic microcarriers display favorable cytocompatibility and drive robust hyaline chondrocyte-derived neocartilage formation. This study paves the way for deciphering the geometrical insights into the interactional mechanism of mechanotransduction in regulating cell fate.
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Research context

Biomaterials

OpenAlex topics: Osteoarthritis Treatment and Mechanisms

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Affiliations

Department of Foot and Ankle Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 P. R. China

State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Chaoyang District Beijing 100101 P. R.China

Beijing Institute for Stem Cell and Regenerative Medicine Chaoyang District Beijing 100101 P. R. China

University of Chinese Academy of Sciences Huairou District Beijing 101499 P. R. China

Beijing Institute of Fashion Technology Beijing 100029 P. R. China

Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 P. R. China

References

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