Delivery Systems Developed for Treatment Combinations to Improve Adoptive Cell Therapy
Source abstract
Abstract
Abstract Adoptive cell therapy (ACT) has shown great success in the clinic for treating hematologic malignancies. However, solid tumor treatment with ACT monotherapy is still challenging, owing to insufficient expansion and rapid exhaustion of adoptive cells, tumor antigen downregulation/loss, and dense tumor extracellular matrix. Delivery strategies for combination cell therapy have great potential to overcome these hurdles. The delivery of vaccines, immune checkpoint inhibitors, cytokines, chemotherapeutics, and photothermal reagents in combination with adoptive cells, have been shown to improve the expansion/activation, decrease exhaustion, and promote the penetration of adoptive cells in solid tumors. Moreover, the delivery of nucleic acids to engineer immune cells directly in vivo holds promise to overcome many of the hurdles associated with the complex ex vivo cell engineering strategies. Here, these research advance, as well as the opportunities and challenges for integrating delivery technologies into cell therapy s are discussed, and the outlook for these emerging areas are criticlly analyzed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: CAR-T cell therapy research · Virus-based gene therapy research · Viral Infectious Diseases and Gene Expression in Insects
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 P.R. China
University of Chinese Academy of Sciences Beijing 100049 P. R. China
Department of Chemistry Center for BioAnalytical Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology New Cornerstone Science Institute Tsinghua University Beijing China
Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230026 China
College of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients Chemical Biology Key Laboratory of Hebei Province Hebei University Baoding 071002 China
College of Biomedical Engineering Guangzhou Medical University Guangzhou 510260 China
References (100+)
Show source-provided references
1. 10.1200/JCO.22.0161810.1200/JCO.22.01618 ↗
2. 10.1186/s40425-017-0222-910.1186/s40425-017-0222-9 ↗
3. 10.1158/2326-6066.CIR-21-050110.1158/2326-6066.CIR-21-0501 ↗
4. 10.1172/JCI9430610.1172/JCI94306 ↗
5. 10.1089/hgtb.2017.09810.1089/hgtb.2017.098 ↗
6. 10.1038/s41586-023-06243-w10.1038/s41586-023-06243-w ↗
7. 10.1002/EXP.2021005810.1002/EXP.20210058 ↗
8. 10.1158/1078-0432.CCR-18-203510.1158/1078-0432.CCR-18-2035 ↗
9. 10.1038/s41586-022-05531-110.1038/s41586-022-05531-1 ↗
10. 10.1038/s41591-019-0599-810.1038/s41591-019-0599-8 ↗
11. 10.1182/blood.202101153210.1182/blood.2021011532 ↗
12. 10.1038/s41571-023-00754-110.1038/s41571-023-00754-1 ↗
13. 10.1038/s41571-023-00848-w10.1038/s41571-023-00848-w ↗
14. 10.3322/caac.2176310.3322/caac.21763 ↗
15. 10.1038/s41591-022-02128-z10.1038/s41591-022-02128-z ↗
16. 10.1038/s41577-021-00539-610.1038/s41577-021-00539-6 ↗
17. 10.1038/s41571-022-00689-z10.1038/s41571-022-00689-z ↗
18. 10.1038/s41571-022-00717-y10.1038/s41571-022-00717-y ↗
19. 10.1186/s12943-023-01755-510.1186/s12943-023-01755-5 ↗
20. 10.1038/s41467-023-40844-310.1038/s41467-023-40844-3 ↗
21. 10.1038/s41591-023-02498-y10.1038/s41591-023-02498-y ↗
22. 10.1038/s41586-022-05257-010.1038/s41586-022-05257-0 ↗
23. 10.1158/1078-0432.CCR-13-301710.1158/1078-0432.CCR-13-3017 ↗
24. 10.4161/onci.2266410.4161/onci.22664 ↗
25. 10.1158/1078-0432.CCR-17-184610.1158/1078-0432.CCR-17-1846 ↗
26. 10.1158/1078-0432.CCR-13-045810.1158/1078-0432.CCR-13-0458 ↗
27. 10.1182/blood-2014-01-55217410.1182/blood-2014-01-552174 ↗
28. 10.1007/s12015-020-10092-910.1007/s12015-020-10092-9 ↗
29. 10.1007/s00262-015-1702-810.1007/s00262-015-1702-8 ↗
30. 10.1126/science.aba178610.1126/science.aba1786 ↗
31. 10.1002/adma.20190019210.1002/adma.201900192 ↗
32. 10.1007/s40264-014-0226-z10.1007/s40264-014-0226-z ↗
33. 10.1016/j.medj.2022.12.00710.1016/j.medj.2022.12.007 ↗
34. 10.1038/s41467-023-40312-y10.1038/s41467-023-40312-y ↗
35. 10.1038/s41467-020-14963-010.1038/s41467-020-14963-0 ↗
36. 10.1038/s41467-020-19540-z10.1038/s41467-020-19540-z ↗
37. 10.1038/s41434-018-0040-910.1038/s41434-018-0040-9 ↗
38. 10.1038/nbt.418110.1038/nbt.4181 ↗
39. 10.1021/nl802404h10.1021/nl802404h ↗
40. 10.1021/nn901319y10.1021/nn901319y ↗
41. 10.1038/nnano.2017.5710.1038/nnano.2017.57 ↗
42. 10.1016/j.addr.2020.06.01910.1016/j.addr.2020.06.019 ↗
43. 10.1038/s41571-022-00719-w10.1038/s41571-022-00719-w ↗
44. 10.1016/j.ymthe.2022.06.01010.1016/j.ymthe.2022.06.010 ↗
45. 10.1038/s41417-020-0189-410.1038/s41417-020-0189-4 ↗
46. 10.1038/s41417-023-00658-310.1038/s41417-023-00658-3 ↗
47. 10.1038/s41591-021-01510-710.1038/s41591-021-01510-7 ↗
48. 10.1126/scitranslmed.abn223110.1126/scitranslmed.abn2231 ↗
49. 10.1126/scitranslmed.aaz186310.1126/scitranslmed.aaz1863 ↗
50. Chen Y. · Nat. Biotechnol. · 2024
51. 10.1038/nbt.272510.1038/nbt.2725 ↗
52. 10.1016/j.immuni.2021.11.00110.1016/j.immuni.2021.11.001 ↗
53. 10.1002/EXP.2021021710.1002/EXP.20210217 ↗
54. 10.1056/NEJMoa203457710.1056/NEJMoa2034577 ↗
55. 10.1126/science.aay596710.1126/science.aay5967 ↗
56. 10.1038/s41591-023-02612-010.1038/s41591-023-02612-0 ↗
57. 10.1016/j.annonc.2022.08.03510.1016/j.annonc.2022.08.035 ↗
58. 10.1039/D1CS00786F10.1039/D1CS00786F ↗
59. 10.1126/science.aav869210.1126/science.aav8692 ↗
60. 10.1038/nature1297810.1038/nature12978 ↗
61. 10.1016/j.cell.2023.06.00210.1016/j.cell.2023.06.002 ↗
62. 10.1038/s41419-020-03221-210.1038/s41419-020-03221-2 ↗
63. 10.1080/2162402X.2018.144672010.1080/2162402X.2018.1446720 ↗
64. 10.1038/s41551-021-00834-610.1038/s41551-021-00834-6 ↗
65. 10.1038/s41467-021-25197-z10.1038/s41467-021-25197-z ↗
66. 10.1038/nnano.2017.11310.1038/nnano.2017.113 ↗
67. 10.1038/s41467-023-39330-710.1038/s41467-023-39330-7 ↗
68. 10.1172/JCI8762410.1172/JCI87624 ↗
69. 10.1038/nbt0202-14310.1038/nbt0202-143 ↗
70. 10.1038/s41573-021-00259-510.1038/s41573-021-00259-5 ↗
71. 10.1038/s41577-020-00454-210.1038/s41577-020-00454-2 ↗
72. 10.1182/blood-2018-99-11152310.1182/blood-2018-99-111523 ↗
73. 10.1158/2159-8290.CD-21-040710.1158/2159-8290.CD-21-0407 ↗
74. 10.1182/bloodadvances.202200869710.1182/bloodadvances.2022008697 ↗
75. 10.3389/fimmu.2021.72896210.3389/fimmu.2021.728962 ↗
76. 10.1001/jamaoncol.2018.392310.1001/jamaoncol.2018.3923 ↗
77. 10.1038/s41571-019-0218-010.1038/s41571-019-0218-0 ↗
78. 10.1126/science.270.5238.908.a10.1126/science.270.5238.908.a ↗
79. 10.1038/s41573-022-00557-610.1038/s41573-022-00557-6 ↗
80. 10.1158/1078-0432.CCR-17-086710.1158/1078-0432.CCR-17-0867 ↗
81. 10.1016/j.omtm.2020.08.00810.1016/j.omtm.2020.08.008 ↗
82. 10.1126/science.aba162410.1126/science.aba1624 ↗
83. 10.1186/s13045-021-01128-910.1186/s13045-021-01128-9 ↗
84. 10.1126/sciadv.abn826410.1126/sciadv.abn8264 ↗
85. 10.1038/s41551-021-00712-110.1038/s41551-021-00712-1 ↗
86. 10.1038/nbt.310410.1038/nbt.3104 ↗
87. Zhang D. K. Y. · Nat. Biomed. Engin. · 2024
88. 10.1002/EXP.2022017310.1002/EXP.20220173 ↗
89. 10.1038/s43018-020-00119-y10.1038/s43018-020-00119-y ↗
90. Shi J. · Nat. Mater. · 2024
91. 10.1038/nchem.220310.1038/nchem.2203 ↗
92. 10.1038/nchem.193710.1038/nchem.1937 ↗
93. 10.1002/EXP.2021013410.1002/EXP.20210134 ↗
94. 10.1038/s41590-019-0441-y10.1038/s41590-019-0441-y ↗
95. 10.1021/acsnano.6b0319410.1021/acsnano.6b03194 ↗
96. 10.1038/nchem.291710.1038/nchem.2917 ↗
97. 10.1016/j.biomaterials.2016.01.02610.1016/j.biomaterials.2016.01.026 ↗
98. 10.1016/j.biomaterials.2010.11.02910.1016/j.biomaterials.2010.11.029 ↗
99. 10.1021/acsnano.8b0714110.1021/acsnano.8b07141 ↗
100. 10.1126/sciadv.aaz657910.1126/sciadv.aaz6579 ↗