Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry
Source abstract
Abstract
Abstract Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer‐scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell‐based assays.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Mass Spectrometry Techniques and Applications · Innovative Microfluidic and Catalytic Techniques Innovation · Microfluidic and Capillary Electrophoresis Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bioengineering and Therapeutic Sciences University of California, San Francisco San Francisco CA 94158 USA
Amyris Inc. 5885 Hollis St #100 Emeryville CA 94608 USA
Institute for Neurodegenerative Diseases Weill Institute for Neurosciences University of California San Francisco CA 94158 USA
Bruker Nano Surfaces San Jose CA 95134 USA
Department of Chemistry University of Michigan Ann Arbor MI 48104 USA
Chan Zuckerberg Biohub San Francisco CA 94158 USA
Funding
Centers for Disease Control and Prevention
References (48)
Show source-provided references
1. 10.1038/s41592-021-01277-210.1038/s41592-021-01277-2 ↗
2. 10.1016/0168-1656(95)00009-F10.1016/0168-1656(95)00009-F ↗
3. 10.1038/nmeth.407110.1038/nmeth.4071 ↗
4. 10.1038/s41592-021-01276-310.1038/s41592-021-01276-3 ↗
5. 10.1073/pnas.120930211010.1073/pnas.1209302110 ↗
6. 10.1021/jacs.7b0464110.1021/jacs.7b04641 ↗
7. 10.1080/0570492080210819810.1080/05704920802108198 ↗
8. 10.1002/rcm.421010.1002/rcm.4210 ↗
9. 10.1038/s41467-020-19040-010.1038/s41467-020-19040-0 ↗
10. 10.1002/rcm.129008090410.1002/rcm.1290080904 ↗
11. 10.1021/acs.analchem.9b0566510.1021/acs.analchem.9b05665 ↗
12. 10.1038/nbt121010.1038/nbt1210 ↗
13. 10.1002/adma.20070081810.1002/adma.200700818 ↗
14. 10.1002/adma.20210299110.1002/adma.202102991 ↗
15. 10.1073/pnas.170402011410.1073/pnas.1704020114 ↗
16. 10.1002/adma.20200534610.1002/adma.202005346 ↗
17. 10.1073/pnas.180223311510.1073/pnas.1802233115 ↗
18. 10.1016/j.aca.2012.12.04410.1016/j.aca.2012.12.044 ↗
19. 10.1007/s13361-016-1406-010.1007/s13361-016-1406-0 ↗
20. 10.1103/PhysRevE.68.03631210.1103/PhysRevE.68.036312 ↗
21. 10.1021/acs.langmuir.5b0023010.1021/acs.langmuir.5b00230 ↗
22. 10.1016/j.jasms.2006.02.00510.1016/j.jasms.2006.02.005 ↗
23. 10.1039/C8CC09945F10.1039/C8CC09945F ↗
24. 10.1021/acs.analchem.5b0428310.1021/acs.analchem.5b04283 ↗
25. 10.1063/1.368739910.1063/1.3687399 ↗
26. 10.1109/JSEN.2012.222771610.1109/JSEN.2012.2227716 ↗
27. 10.1021/am500367h10.1021/am500367h ↗
28. 10.1002/bit.2725710.1002/bit.27257 ↗
29. 10.1016/j.optcom.2014.12.07110.1016/j.optcom.2014.12.071 ↗
30. 10.1016/j.ijleo.2013.10.08210.1016/j.ijleo.2013.10.082 ↗
31. 10.1039/C5LC01499A10.1039/C5LC01499A ↗
32. 10.1007/s10544-008-9216-110.1007/s10544-008-9216-1 ↗
33. 10.1002/adhm.20120007010.1002/adhm.201200070 ↗
34. 10.1002/pmic.20060018410.1002/pmic.200600184 ↗
35. 10.1038/nprot.2010.17610.1038/nprot.2010.176 ↗
36. 10.1088/0960-1317/7/3/01010.1088/0960-1317/7/3/010 ↗
37. 10.1016/j.msec.2013.07.00110.1016/j.msec.2013.07.001 ↗
38. 10.1038/nature1034410.1038/nature10344 ↗
39. 10.1002/adma.20090114110.1002/adma.200901141 ↗
40. 10.1088/1758-5082/2/1/01410410.1088/1758-5082/2/1/014104 ↗
41. 10.1038/srep4503610.1038/srep45036 ↗
42. 10.1021/acs.analchem.8b0450610.1021/acs.analchem.8b04506 ↗
43. Armbruster D. A. · Clin. Biochem. Rev. · 2008 · 29 · S49
44. 10.1007/s00216-011-5194-x10.1007/s00216-011-5194-x ↗
45. 10.1002/(SICI)1096-9888(200001)35:1<1::AID-JMS904>3.0.CO;2-010.1002/(SICI)1096-9888(200001)35:1<1::AID-JMS904>3.0.CO;2-0 ↗
46. 10.1016/j.ymben.2019.11.00610.1016/j.ymben.2019.11.006 ↗
47. 10.1007/s00253000051110.1007/s002530000511 ↗
48. 10.1038/s41467-021-27185-910.1038/s41467-021-27185-9 ↗