DataVXAdvanced MaterialsPaper
journal article·2019-12Open access

Biosensors: CRISPR/Cas13a‐Powered Electrochemical Microfluidic Biosensor for Nucleic Acid Amplification‐Free miRNA Diagnostics (Adv. Mater. 51/2019)

Richard Bruch, Julia Baaske, Claire Chatelle, Mailin Meirich, Sibylle Madlener, Wilfried Weber, Can Dincer, Gerald Anton Urban

Advanced Materials· Volume 31· Issue 51
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Source abstract

Abstract

In article number 1905311, Can Dincer and co-workers introduce the first CRISPR-powered electrochemical microfluidic biosensor (CRISPR-Biosensor), allowing nucleic-acid-amplification-free detection of microRNAs in isolated serum samples. Upon recognition of its target, the activated Cas13a cleaves reporter RNAs in its surroundings, resulting in a decrease of the measured electrochemical signals. The CRISPR-Biosensor offers a low-cost, easily scalable, specific, and target amplification-free (i.e., rapid and easy-to-use) tool for on-site nucleic acid diagnostics.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques

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Affiliations

Department of Microsystems Engineering (IMTEK) Laboratory for Sensors University of Freiburg Georges‐Koehler Allee 103 79110 Freiburg Germany

Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT) University of Freiburg Georges‐Koehler‐Allee 105 79110 Freiburg Germany

Faculty of Biology and Signalling Research Centres BIOSS and CIBSS University of Freiburg Schaenzlestraße 18 79104 Freiburg Germany

Department of Pediatrics and Adolescent Medicine Molecular Neuro‐Oncology Medical University of Vienna Waehringer Guertel 18‐20 1090 Vienna Austria

Department of Bioengineering Royal School of Mines Imperial College London SW7 2AZ London UK

Freiburg Materials Research Center (FMF) University of Freiburg Stefan‐Meier‐Straße 21 79104 Freiburg Germany

References

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