Gene Delivery: Fusogenic Reactive Oxygen Species Triggered Charge‐Reversal Vector for Effective Gene Delivery (Adv. Mater. 9/2016)
Source abstract
Abstract
On page 1743, Y. Shen and co-workers describe the design of a novel fusogenic lipidic polyplex (FLPP) vector, which fuses with cell membranes, mimicking viropexis and ejecting the polyplex into the cytosol. There, the cationic polymer is oxidized by intracellular reaction oxygen species, becomes negatively charged, and releases DNA efficiently. This vector delivering suicide genes achieves significantly better inhibition of tumor growth than doxorubicin, making it a candidate for further study in gene therapy and cancer treatment.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques
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Affiliations
Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China
Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China
Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China
References
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