DataVXAdvanced MaterialsPaper
journal article·2018-12Open access

Construction of a Novel Bispecific Antibody to Enhance Antitumor Activity against Lung Cancer

Wei Yin, Junjie Zhu, Diego Gonzalez‐Rivas, Meinoshin Okumura, Gaetano Rocco, Harvey Pass, Gening Jiang, Yang Yang

Advanced Materials· Volume 30· Issue 51
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Source abstract

Abstract

Abstract HER2 and VEGF are closely related to the progression of several tumors. The inhibitor simultaneously targeting these two proteins will effectively inhibit the progression of tumors. Here, a bispecific antibody, termed as YY0411, targeting both HER2 and VEGF as a potent anticancer therapeutic antibody is reported. YY0411 is the first bispecific antibody constructed in IgG‐Decoy receptor format. It efficiently identifies and combines both HER2 and VEGF protein. YY0411 is believed to be a candidate tumor suppressor as it significantly inhibits the colony formation ability of human cancer cells (Calu‐3, MDA‐MB‐453, and NCI‐N87 cells). The phosphorylation of HER2 and VEGF downstream components are also decreased in these cells with the treatment of YY0411. Similar to other antibodies, YY0411 has the ability to promote the secretion of IFN‐γ by T lymphocytes. In addition, YY0411 significantly inhibits the growth of Calu‐3 cells‐induced xenograft in nude mice. This work demonstrates that YY0411 may be a potential anti‐lung cancer drug.
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Research context

OpenAlex topics: Glycosylation and Glycoproteins Research · Monoclonal and Polyclonal Antibodies Research · Galectins and Cancer Biology

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key laboratory of Oral Biomedical engineering of Ministry of education Hospital of Stomatology School of Stomatology Wuhan University Wuhan 430079 China

Department of Thoracic Surgery Shanghai Pulmonary Hospital 507 Zhengmin Road Shanghai 200433 China

Department of thoracic surgery and Minimally Invasive Thoracic Surgery Unit (UCTMI). Coruña University Hospital Coruña 15706 Spain

Hospital Director Toneyama National Hospital Osaka 560‐8552 Japan

Thoracic Service Department of Surgery Memorial Sloan‐Kettering Cancer Center NY 10065 USA

Department of Cardiothoracic Surgery NYU Langone Medical Center NY 10016 USA

Institute for Advanced Study Tongji University 1239 Siping Road Shanghai 200430 China

Funding

National Natural Science Foundation of China · Foundation of Shanghai Municipal Commission of Health and Family Planning

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