DataVXAdvanced MaterialsPaper
journal article·2018-08Open access

Photodynamic Therapy: Responsive Assembly of Upconversion Nanoparticles for pH‐Activated and Near‐Infrared‐Triggered Photodynamic Therapy of Deep Tumors (Adv. Mater. 35/2018)

Fangyuan Li, Yang Du, Jianan Liu, Heng Sun, Jin Wang, Ruiqing Li, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling

Advanced Materials· Volume 30· Issue 35
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Source abstract

Abstract

Stimuli-responsive smart photodynamic agents are highly desirable for photodynamic therapy. In article number 1802808, Daishun Ling and co-workers report tumor-pH-sensitive photodynamic nanoagents composed of self-assembled photosensitizer-grafted pH-responsive polymeric ligands and upconversion nanoparticles (UCNPs). The nanoagents are self-quenched in physiological pH conditions. In a mild acidic tumor environment, they can be efficiently internalized by tumor cells due to surface charge reversal, and further become disassembled into well-dispersed nanoparticles in intracellular tumor pH value, resulting in the UCNP-mediated activation of photosensitizers by near-infrared light.
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Research context

PolymersNanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Advanced Nanomaterials in Catalysis

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Affiliations

Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou Zhejiang 310058 P. R. China

Center for Nanoparticle Research Institute for Basic Science (IBS) Seoul 08826 Republic of Korea

School of Chemical and Biological Engineering Seoul National University Seoul 08826 Republic of Korea

Key Laboratory of Biomedical Engineering of the Ministry of Education College of Biomedical Engineering & Instrument Science Zhejiang University Hangzhou Zhejiang 310027 P. R. China

References

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