A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration
Source abstract
Abstract
A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postculture by the simple process of lowering the temperature and applying an external magnetic field. The colloidal gel can be reconfigured with thermal and magnetic stimuli to allow patterning of cells in discrete zones and to control movement of cells within the porous matrix during culture.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Pharmacy University of East Anglia Norwich NR4 7TJ UK
School of Pharmacy University of Nottingham Nottingham NG7 2RD UK
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Vienna Austria
School of Materials University of Manchester Manchester M13 9PL UK
Funding
EPSRC Centre for Innovative Manufacturing in Regenerative Medicine · EPSRC · FP7 EU Biodesign Programme
References (26)
Show source-provided references
1. 10.1038/nmat397210.1038/nmat3972 ↗
2. 10.1016/j.yjmcc.2010.06.01010.1016/j.yjmcc.2010.06.010 ↗
3. 10.1002/ana.2248710.1002/ana.22487 ↗
4. 10.1155/2014/95151210.1155/2014/951512 ↗
5. 10.1007/s00441-012-1441-510.1007/s00441-012-1441-5 ↗
6. 10.1038/nrm223610.1038/nrm2236 ↗
7. 10.1021/pr500064m10.1021/pr500064m ↗
8. 10.1002/adma.20130550610.1002/adma.201305506 ↗
9. 10.1016/j.biomaterials.2009.01.01010.1016/j.biomaterials.2009.01.010 ↗
10. 10.1038/nmat256310.1038/nmat2563 ↗
11. 10.1038/nnano.2008.27010.1038/nnano.2008.270 ↗
12. 10.1002/jbm.b.3137610.1002/jbm.b.31376 ↗
13. 10.1038/nprot.2008.4010.1038/nprot.2008.40 ↗
14. 10.1016/S1369-703X(03)00124-410.1016/S1369-703X(03)00124-4 ↗
15. 10.1186/1423-0127-17-3610.1186/1423-0127-17-36 ↗
16. 10.1016/j.jcyt.2013.10.00310.1016/j.jcyt.2013.10.003 ↗
17. 10.1205/cherd0619610.1205/cherd06196 ↗
18. 10.1002/btpr.47110.1002/btpr.471 ↗
19. 10.1007/s12015-013-9428-510.1007/s12015-013-9428-5 ↗
20. 10.1002/mabi.20110047710.1002/mabi.201100477 ↗
21. 10.1039/c0sm00059k10.1039/c0sm00059k ↗
22. 10.1002/adma.20080038210.1002/adma.200800382 ↗
23. 10.1021/la903659z10.1021/la903659z ↗
24. 10.1038/pj.2011.8310.1038/pj.2011.83 ↗
25. 10.1080/1465324060085590510.1080/14653240600855905 ↗
26. 10.1002/bit.2452910.1002/bit.24529 ↗