Reversible Non‐Stick Behaviour of a Bacterial Protein Polymer Provides a Tuneable Molecular Mimic for Cell and Tissue Engineering
Source abstract
Abstract
Yersina pestis, the bubonic plague bacterium, is coated with a polymeric protein hydrogel for protection from host defences. The protein, which is robust and non-stick, resembles structures found in many eukaryotic extracellular-matrix proteins. Cells grown on the natural polymer cannot adhere and grow poorly; however, when cell-adhesion motifs are inserted into the protein, the cells proliferate.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Yersinia bacterium, plague, ectoparasites research · Bacterial Genetics and Biotechnology · Biochemical and Structural Characterization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute for Cell and Molecular Biosciences Newcastle University Newcastle upon Tyne NE2 4HH United Kingdom
Institute for Cellular Medicine Newcastle University Newcastle upon Tyne NE2 4HH United Kingdom
Orla Protein Technologies Ltd International Centre for Life Times Square Newcastle upon Tyne NE1 4EP UK
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