journal article·2017-02Open access

Converting Red Blood Cells to Efficient Microreactors for Blood Detoxification

Can Xu, Xiangyu Yang, Xiao Fu, Rui Tian, Orit Jacobson, Zhantong Wang, Nan Lu, Yijing Liu, Wenpei Fan, Fuwu Zhang, Gang Niu, Shuo Hu, Iqbal Unnisa Ali, Xiaoyuan Chen

Advanced Materials· Volume 29· Issue 6

Abstract

A simple method to convert red blood cells (RBCs) into efficient microreactors is reported. Triton X-100 is employed at finely tuned concentrations to render RBCs highly permeable to substrates, while low concentrations of glutaraldehyde are used to stabilize cells. The ability for blood detoxification of these microreactors is demonstrated. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Erythrocyte Function and Pathophysiology · Hemoglobin structure and function · Lipid Membrane Structure and Behavior

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of PET Center Xiangya Hospital Central South University Changsha 410008 China

Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) Bethesda, MD 20892 USA

References (59)

Show source-provided references
1. 10.1002/adhm.20120013810.1002/adhm.201200138 ↗
2. 10.1517/1742524100361063310.1517/17425241003610633 ↗
3. 10.1016/j.jconrel.2003.11.01810.1016/j.jconrel.2003.11.018 ↗
4. 10.1038/nbt84610.1038/nbt846 ↗
5. 10.4155/tde.15.3410.4155/tde.15.34 ↗
6. 10.1039/C1CS15240H10.1039/C1CS15240H ↗
7. Kotyk A. · 1970
8. 10.1073/pnas.70.9.266310.1073/pnas.70.9.2663 ↗
9. 10.1002/978352762810010.1002/9783527628100 ↗
10. Scherz R. G. · Paediatrician · 1977 · 6 · 190
11. 10.1016/j.jbspin.2012.01.00410.1016/j.jbspin.2012.01.004 ↗
12. Westley J. · 1981 · 285
13. 10.1177/01926233000280030510.1177/019262330002800305 ↗
14. Liska D. J. · Altern. Med. Rev. · 1998 · 3 · 187
15. 10.1056/NEJM19920618326250710.1056/NEJM199206183262507 ↗
16. 10.1016/j.addr.2015.05.00510.1016/j.addr.2015.05.005 ↗
17. 10.1038/nnano.2007.33910.1038/nnano.2007.339 ↗
18. 10.1016/S1389-0344(01)00088-010.1016/S1389-0344(01)00088-0 ↗
19. 10.1517/17425247.2014.88967910.1517/17425247.2014.889679 ↗
20. 10.2147/DDDT.S9647010.2147/DDDT.S96470 ↗
21. 10.1016/S0005-2736(01)00418-710.1016/S0005-2736(01)00418-7 ↗
22. 10.1083/jcb.32.1.5510.1083/jcb.32.1.55 ↗
23. 10.1085/jgp.42.1.910.1085/jgp.42.1.9 ↗
24. 10.1038/215424a010.1038/215424a0 ↗
25. 10.1038/184723a010.1038/184723a0 ↗
26. 10.1039/B612870J10.1039/B612870J ↗
27. 10.1016/S1387-2656(03)09003-310.1016/S1387-2656(03)09003-3 ↗
28. 10.1016/0005-2795(67)90410-210.1016/0005-2795(67)90410-2 ↗
29. 10.1097/00007890-196411000-0000110.1097/00007890-196411000-00001 ↗
30. 10.1039/b802497a10.1039/b802497a ↗
31. 10.1111/j.1470-8744.1992.tb00222.x10.1111/j.1470-8744.1992.tb00222.x ↗
32. 10.1016/j.etap.2013.03.02010.1016/j.etap.2013.03.020 ↗
33. 10.1016/j.jbiomech.2014.03.03810.1016/j.jbiomech.2014.03.038 ↗
34. 10.1039/C4LC01100G10.1039/C4LC01100G ↗
35. 10.1016/j.ijpharm.2005.05.02810.1016/j.ijpharm.2005.05.028 ↗
36. 10.1126/science.164.3880.71710.1126/science.164.3880.717 ↗
37. 10.1073/pnas.101001310810.1073/pnas.1010013108 ↗
38. 10.1016/j.jbbm.2005.11.00310.1016/j.jbbm.2005.11.003 ↗
39. 10.1007/s11427-012-4399-310.1007/s11427-012-4399-3 ↗
40. 10.3389/fphys.2014.0008410.3389/fphys.2014.00084 ↗
41. 10.1371/journal.pone.015207410.1371/journal.pone.0152074 ↗
42. 10.1172/JCI10812910.1172/JCI108129 ↗
43. 10.1007/BF0086158810.1007/BF00861588 ↗
44. 10.2741/395010.2741/3950 ↗
45. 10.1073/pnas.86.23.941210.1073/pnas.86.23.9412 ↗
46. Gochman N. · Clin. Chem. · 1971 · 17 · 115410.1093/clinchem/17.12.1154 ↗
47. 10.1186/1758-5996-4-1210.1186/1758-5996-4-12 ↗
48. Graham D. L. · Arch. Intern. Med. · 1977 · 137 · 105110.1001/archinte.1977.03630200055016 ↗
49. 10.1006/faat.1994.108010.1006/faat.1994.1080 ↗
50. Leung P. · Fed. Proc. · 1985 · 44 · 718
51. 10.1016/S0024-3205(01)00991-210.1016/S0024-3205(01)00991-2 ↗
52. 10.1177/00359157620550021110.1177/003591576205500211 ↗
53. 10.1016/S0001-2998(84)80022-710.1016/S0001-2998(84)80022-7 ↗
54. 10.3402/jev.v4.2631610.3402/jev.v4.26316 ↗
55. 10.1172/JCI11054810.1172/JCI110548 ↗
56. 10.1152/ajpregu.1998.275.5.R158410.1152/ajpregu.1998.275.5.R1584 ↗
57. 10.1189/jlb.080542610.1189/jlb.0805426 ↗
58. 10.3109/15563650.2010.50519710.3109/15563650.2010.505197 ↗
59. 10.1097/00008877-200609000-0003810.1097/00008877-200609000-00038 ↗