Directed Axonal Outgrowth Using a Propagating Gradient of IGF‐1
Source abstract
Abstract
The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivity or re-connectivity of neurons in neurological injury or disease. Here we report the successful construction of a biocompatible guidance device, in which a linear propagation of IGF-1 gradient sequentially directs axon outgrowth. We observe the extensive in vitro axonal extension over 5 mm with a desired growth rate of ∼ 1 mm/day.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Axon Guidance and Neuronal Signaling · Nerve injury and regeneration · Neurogenesis and neuroplasticity mechanisms
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Neurosurgery Stanford University Stanford CA USA
Department of Chemical Engineering Stanford University Stanford CA USA
References (21)
Show source-provided references
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