journal article·2006-06-19Open access

Shear‐Stress Profile along a Cell Focal Adhesion

D. Raz–Ben Aroush, H. D. Wagner

Advanced Materials· Volume 18· Issue 12

Abstract

Cell–substrate adhesion, such as for the porcine aortic endothelial cell shown in the figure, is investigated using a shear-lag type mechanical model classically used in composite material science. The shape of the shear-stress profile along the cell/substrate interface suggests a likely mechanism for the biochemical feedback activity leading to a growth of the adhesion region. The role of various material and geometrical characteristics of the adhesion region is predicted.
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Research context

OpenAlex topics: Cellular Mechanics and Interactions · Elasticity and Material Modeling · Force Microscopy Techniques and Applications

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