journal article·2013-10-11

LHRH‐PE40 Fusion Protein Tethered Silica Nanorattles for Imaging‐Guided Tumor‐Specific Drug Delivery and Bimodal Therapy

Fuping Gao, Linlin Li, Changhui Fu, Liya Nie, Dong Chen, Fangqiong Tang

Advanced Materials· Volume 25· Issue 38
Publisher page

Abstract

Docyanine green (ICG) and LHRH-PE40 fusion protein are tethered onto drug carriers of silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy. The synergistic therapeutic effect of toxin PE40 and the chemotherapeutic drug docetaxel (Dtxl), specifically directed by LHRH to cancer, improves cancer treatment. Simultaneously, ICG enables real-time monitoring of the silica nanocomposites and therapeutic response.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · Nanoparticle-Based Drug Delivery

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