Modulating Neuronal Responses by Controlled Integration of Acetylcholine‐like Functionalities in Biomimetic Polymers

This paper describes a new pathway to neuroactive materials that relies on integration of neurotransmitter-like functional groups into synthetic polymers. A series of biodegradable polymers are synthesized with varying concentrations of acetylcholine-like functionalities (ALFs) using a modular design. The polymers with medium ALF contents resemble laminin in promoting neurite sprouting and extension while maintaining phenotypic protein expression of neurons.