journal article·2014-05Open access

Developmentally‐Inspired Shrink‐Wrap Polymers for Mechanical Induction of Tissue Differentiation

Basma Hashmi, Lauren D. Zarzar, Tadanori Mammoto, Akiko Mammoto, Amanda Jiang, Joanna Aizenberg, Donald E. Ingber

Advanced Materials· Volume 26· Issue 20

Abstract

A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This normally occurs during the physiological mesenchymal condensation response that triggers tooth formation in the embryo.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · 3D Printing in Biomedical Research · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Wyss Institute for Biologically Inspired Engineering Harvard University Boston MA 02115 USA

Harvard School of Engineering and Applied Sciences Cambridge MA 02138 USA

Department of Chemistry and Chemical Biology Harvard University Cambridge MA 02138 USA

Vascular Biology Program Boston Children's Hospital and Harvard Medical School Boston MA 02115 USA

References (32)

Show source-provided references
1. 10.1016/j.devcel.2011.07.00610.1016/j.devcel.2011.07.006 ↗
2. 10.1038/nmat244110.1038/nmat2441 ↗
3. 10.1038/nature0860110.1038/nature08601 ↗
4. 10.1126/science.152.3718.2510.1126/science.152.3718.25 ↗
5. Grobstein C. · Natl. Cancer Inst. Monogr. · 1967 · 26 · 279
6. Bernfield M. · Ciba Found. Symp. · 1984 · 108 · 179
7. Gurdon J. B. · Development · 1987 · 99 · 28510.1242/dev.99.3.285 ↗
8. Saxén L. · Ciba Found. Symp. · 1992 · 165 · 183
9. 10.1016/S0925-4773(99)00322-610.1016/S0925-4773(99)00322-6 ↗
10. 10.1016/0003-9969(87)90055-010.1016/0003-9969(87)90055-0 ↗
11. Bei M. · Development · 2000 · 127 · 471110.1242/dev.127.21.4711 ↗
12. 10.1038/172869a010.1038/172869a0 ↗
13. 10.1016/0012-1606(62)90042-810.1016/0012-1606(62)90042-8 ↗
14. 10.1111/j.1469-185X.1990.tb01427.x10.1111/j.1469-185X.1990.tb01427.x ↗
15. 10.1007/BF0017494810.1007/BF00174948 ↗
16. Thesleff I. · Int. J. Dev. Biol. · 1995 · 39 · 35
17. 10.1039/c004732e10.1039/c004732e ↗
18. 10.1002/adma.20120180510.1002/adma.201201805 ↗
19. 10.1016/j.actbio.2010.12.02710.1016/j.actbio.2010.12.027 ↗
20. 10.1016/j.addr.2006.09.02010.1016/j.addr.2006.09.020 ↗
21. 10.1016/0079-6700(92)90023-R10.1016/0079-6700(92)90023-R ↗
22. 10.1016/j.ejpb.2007.02.02510.1016/j.ejpb.2007.02.025 ↗
23. 10.1002/(SICI)1097-4636(199802)39:2<266::AID-JBM14>3.0.CO;2-B10.1002/(SICI)1097-4636(199802)39:2<266::AID-JBM14>3.0.CO;2-B ↗
24. 10.1016/S0142-9612(03)00343-010.1016/S0142-9612(03)00343-0 ↗
25. 10.1016/S8756-3282(01)00617-210.1016/S8756-3282(01)00617-2 ↗
26. 10.1080/00016359842824810.1080/000163598428248 ↗
27. 10.1242/jcs.0041010.1242/jcs.00410 ↗
28. 10.1177/15440591040830070210.1177/154405910408300702 ↗
29. 10.1073/pnas.100786210810.1073/pnas.1007862108 ↗
30. 10.1021/bm201545u10.1021/bm201545u ↗
31. 10.1016/j.cell.2009.10.02710.1016/j.cell.2009.10.027 ↗
32. 10.1007/s10911-004-1404-x10.1007/s10911-004-1404-x ↗