journal article·2026-02

Magnetic Mesoporous Nanoparticles Loaded with Lycium barbarum Glycopeptide for Targeted Therapy of Noise‐Triggered Auditory Dysfunction

Menghui Liao, Qian Zhu, Hong Cheng, Yuyang Qiu, Shan Xu, Chuan Bu, Wenyan Song, Jiazhe Xue, Xugang Zhuang, Yusong Wang, Xinyi Pang, Hao Wei, Yangnan Hu, Renjie Chai

Advanced Materials· Volume 38· Issue 12
Publisher page

Abstract

ABSTRACT Hearing loss, primarily caused by the irreversible loss of cochlear hair cells and spiral ganglion neurons, represents a major clinical challenge. Due to factors such as the blood‐labyrinth barrier and the unique structure of the cochlea, there is still a lack of an effective and sustainable targeted drug delivery system. The development of inner ear drug delivery systems capable of sustaining therapeutic concentrations with site‐specific localization remains a critical challenge in otopharmacology. In this paper, we engineered a magnetically navigable platform utilizing mesoporous silica nanoparticles (MMSNs) for precision‐targeted cochlear drug administration. This system features a magnetic‐responsive core and a permeable porous shell, combining the advantages of both nanomaterial carriers and Lycium barbarum glycopeptide (LbGP). The resultant MMSNs‐LbGP nanocomposite exhibited good biocompatibility, antioxidant, and anti‐inflammatory activities. In a guinea pig model of noise‐induced hearing loss, MMSNs‐LbGP treatment not only effectively restored auditory function and preserved cochlear hair cell structure but also significantly attenuated cochlear neuroinflammation and oxidative damage. This advancement establishes a novel framework for translational implementation of nanoparticle‐mediated inner ear therapy, offering therapeutic solutions to rehabilitate or functionally augment auditory pathways in patients with sensorineural deficits.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Hearing, Cochlea, Tinnitus, Genetics · Vestibular and auditory disorders · Advanced Drug Delivery Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Otolaryngology Head and Neck Surgery Zhongda Hospital State Key Laboratory of Digital Medical Engineering Jiangsu Provincial Key Laboratory of Critical Care Medicine School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Southeast University Nanjing China

School of Medical Engineering Affiliated Zhuhai People's Hospital Beijing Institute of Technology Zhuhai China

Co‐innovation Center of Neuroregeneration Nantong University Nantong China

Department of Rehabilitation Medicine Zhongda Hospital Southeast University Nanjing China

Department of Otolaryngology The First Hospital of China Medical University Shenyang China

The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People's Hospital of Lianyungang Xuzhou China

The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People's Hospital of Lianyungang Lianyungang China

Department of Otolaryngology Head and Neck Surgery The First Affiliated Hospital of Anhui Medical University Hefei China

Department of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan Shandong China

College of Food Science and Engineering Nanjing University of Finance and Economics Nanjing China

Department of Otolaryngology Head and Neck Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Jiangsu Provincial Key Medical Discipline (Laboratory) Nanjing University Nanjing China

Department of Neurology Aerospace Center Hospital School of Life Science Beijing Institute of Technology Beijing China

Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Southeast University Shenzhen Research Institute Shenzhen China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Natural Science Foundation of Jiangsu Province

References (55)

Show source-provided references
1. 10.1152/physrev.00053.201710.1152/physrev.00053.2017 ↗
2. 10.7326/M20-132210.7326/M20-1322 ↗
3. 10.1021/acsnano.2c0630610.1021/acsnano.2c06306 ↗
4. 10.3389/fphar.2021.63350510.3389/fphar.2021.633505 ↗
5. 10.1016/j.compbiomed.2024.10953910.1016/j.compbiomed.2024.109539 ↗
6. 10.1001/jamanetworkopen.2022.3344110.1001/jamanetworkopen.2022.33441 ↗
7. 10.1016/j.neuron.2012.09.03110.1016/j.neuron.2012.09.031 ↗
8. 10.1016/j.redox.2019.10140610.1016/j.redox.2019.101406 ↗
9. 10.1016/j.biopha.2023.11539910.1016/j.biopha.2023.115399 ↗
10. 10.1021/acsnano.4c1267610.1021/acsnano.4c12676 ↗
11. 10.1126/scitranslmed.aao093510.1126/scitranslmed.aao0935 ↗
12. 10.1016/j.jconrel.2024.06.04310.1016/j.jconrel.2024.06.043 ↗
13. 10.1016/j.ejpb.2024.11439310.1016/j.ejpb.2024.114393 ↗
14. 10.2217/nnm.10.8810.2217/nnm.10.88 ↗
15. 10.1016/j.jconrel.2018.04.02810.1016/j.jconrel.2018.04.028 ↗
16. 10.3389/fnmol.2019.0022910.3389/fnmol.2019.00229 ↗
17. 10.3389/fbioe.2021.80944310.3389/fbioe.2021.809443 ↗
18. 10.3389/fncel.2019.0049310.3389/fncel.2019.00493 ↗
19. 10.1016/j.addr.2016.01.00410.1016/j.addr.2016.01.004 ↗
20. 10.1002/advs.20240879810.1002/advs.202408798 ↗
21. 10.1021/acsnano.9b0669110.1021/acsnano.9b06691 ↗
22. 10.1126/sciadv.aax503210.1126/sciadv.aax5032 ↗
23. 10.1021/acsomega.9b0415010.1021/acsomega.9b04150 ↗
24. 10.1016/j.jconrel.2025.02.06010.1016/j.jconrel.2025.02.060 ↗
25. 10.1016/j.envres.2023.11645710.1016/j.envres.2023.116457 ↗
26. 10.1002/advs.20240763710.1002/advs.202407637 ↗
27. 10.1002/advs.20241056810.1002/advs.202410568 ↗
28. 10.3389/fncel.2021.81528010.3389/fncel.2021.815280 ↗
29. 10.1002/smll.20180515910.1002/smll.201805159 ↗
30. 10.2147/IJN.S31367310.2147/IJN.S313673 ↗
31. 10.1021/acsami.4c0232510.1021/acsami.4c02325 ↗
32. 10.1038/nnano.2011.9510.1038/nnano.2011.95 ↗
33. 10.1002/anie.20191169010.1002/anie.201911690 ↗
34. 10.1002/adma.20140112410.1002/adma.201401124 ↗
35. 10.1016/j.apsb.2024.12.01510.1016/j.apsb.2024.12.015 ↗
36. 10.1039/C7TB01217A10.1039/C7TB01217A ↗
37. 10.1021/ja507767h10.1021/ja507767h ↗
38. 10.1039/D1CS00659B10.1039/D1CS00659B ↗
39. 10.1002/smll.20140176710.1002/smll.201401767 ↗
40. 10.1016/j.carbpol.2022.11961810.1016/j.carbpol.2022.119618 ↗
41. 10.1016/j.apsb.2023.11.00110.1016/j.apsb.2023.11.001 ↗
42. 10.3390/biom909038910.3390/biom9090389 ↗
43. 10.1016/j.intimp.2025.11451810.1016/j.intimp.2025.114518 ↗
44. 10.1186/s12967-023-04648-910.1186/s12967-023-04648-9 ↗
45. 10.1016/j.phymed.2023.15486410.1016/j.phymed.2023.154864 ↗
46. 10.1016/j.phymed.2024.15561010.1016/j.phymed.2024.155610 ↗
47. 10.3389/fncel.2017.0028810.3389/fncel.2017.00288 ↗
48. 10.4103/1673-5374.38936010.4103/1673-5374.389360 ↗
49. 10.1371/journal.pone.008133910.1371/journal.pone.0081339 ↗
50. 10.1038/s41417-023-00620-310.1038/s41417-023-00620-3 ↗
51. 10.1038/s41417-023-00611-410.1038/s41417-023-00611-4 ↗
52. 10.1002/advs.20240585010.1002/advs.202405850 ↗
53. 10.1038/s41598-017-01142-310.1038/s41598-017-01142-3 ↗
54. 10.1016/j.omtn.2022.07.01610.1016/j.omtn.2022.07.016 ↗
55. 10.1155/2020/394916110.1155/2020/3949161 ↗