DataVXAdvanced MaterialsPaper
journal article·2026-02

Endogenous Metal Ion‐Enriched Immunostimulating Biomimetic Scaffold Improves In Situ Bone Regeneration

Min Yu, Liyuan Chen, Xinjia Cai, Shengjie Cui, Zixin Li, Chengye Ding, He Zhang, Hangbo Liu, Chang Li, Shiying Zhang, Xinmeng Shi, Ting Zhang, Yunsong Liu, Dan Luo, Yan Liu, Yongsheng Zhou

Advanced Materials· Volume 38· Issue 11
Publisher page
Source abstract

Abstract

ABSTRACT Effective in situ regeneration and functional reconstruction of large‐scale bone defects remain a formidable clinical challenge. The endogenous metal ions have been shown to critically regulate immune responses and bone remodeling, but methods for precisely regulating the spatiotemporal recruitment dynamics of endogenous ions are still lacking. Here, we develop a novel endogenous metal ion‐enriched immunostimulation‐amplified bone biomimetic scaffold (emia‐BBS) based on the hierarchical multi‐level assembly of nano‐hydroxyapatites (nHAs), collagen fibrils, and mussel adhesion proteins (MAPs). The emia‐BBS not only mimics the nanostructure and mechanical properties of native bone, but notably, the assembled MAPs endow emia‐BBS with abundant lysine and dopamine chemical structures, enabling efficient capture of endogenous metal ions to amplify ion‐mediated immunomodulation. Functionally, in large‐scale mandibular defects, emia‐BBS‐induced enrichment of endogenous metal ions could recruit and reprogram macrophages, thereby enhancing the innate immune response. These M2 macrophages, recruited by the emia‐BBS‐metal ion complex, in turn, facilitate the recruitment and osteogenic activation of endogenous LepR⁺ skeletal stem cells via the CCL5/CCR5/STAT3 axis. This study introduces an immunomodulatory strategy that harnesses endogenous ion dynamics to amplify regenerative signals, providing a precisely guided and clinically applicable approach for critical‐sized bone defect repair.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Supramolecular Self-Assembly in Materials · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Central Laboratory, Department of Orthodontics Peking University School and Hospital for Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, National Engineering Research Center of Oral...

Department of Prosthodontics Peking University School and Hospital for Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, National Engineering Research Center of Oral Biomaterials and...

Department of General Dentistry Peking University School and Hospital for Stomatology Beijing P. R. China

Department of Stomatology Peking University People's Hospital Beijing P. R. China

Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing P. R. China

Funding

National Key Research and Development Program of China · Natural Science Foundation of Beijing Municipality · China Postdoctoral Science Foundation · National Natural Science Foundation of China

References (42)

Show source-provided references
1. 10.1038/nature0703910.1038/nature07039 ↗
2. 10.1038/s41578-018-0027-610.1038/s41578-018-0027-6 ↗
3. 10.1038/s41578-020-0209-x10.1038/s41578-020-0209-x ↗
4. 10.1038/s41578-020-0204-210.1038/s41578-020-0204-2 ↗
5. 10.1002/adma.20231087610.1002/adma.202310876 ↗
6. 10.1002/adma.20220204410.1002/adma.202202044 ↗
7. 10.1002/adma.20240364110.1002/adma.202403641 ↗
8. 10.1038/s41467-021-27816-110.1038/s41467-021-27816-1 ↗
9. 10.1016/j.biomaterials.2014.10.04910.1016/j.biomaterials.2014.10.049 ↗
10. 10.1038/s41584-022-00887-010.1038/s41584-022-00887-0 ↗
11. 10.1016/j.immuni.2016.02.01510.1016/j.immuni.2016.02.015 ↗
12. 10.1016/j.biomaterials.2017.12.02510.1016/j.biomaterials.2017.12.025 ↗
13. 10.7150/thno.3950710.7150/thno.39507 ↗
14. 10.1002/adfm.20220863910.1002/adfm.202208639 ↗
15. 10.1016/j.biomaterials.2022.12160410.1016/j.biomaterials.2022.121604 ↗
16. 10.1016/j.bioactmat.2020.11.00410.1016/j.bioactmat.2020.11.004 ↗
17. 10.1002/adma.20160262810.1002/adma.201602628 ↗
18. 10.1002/adfm.20180644510.1002/adfm.201806445 ↗
19. 10.1038/s41551-024-01221-710.1038/s41551-024-01221-7 ↗
20. 10.1073/pnas.060785210410.1073/pnas.0607852104 ↗
21. 10.1126/science.114724110.1126/science.1147241 ↗
22. 10.1126/science.212.4498.103810.1126/science.212.4498.1038 ↗
23. 10.1016/j.smaim.2020.10.00510.1016/j.smaim.2020.10.005 ↗
24. 10.1016/j.biomaterials.2015.01.03310.1016/j.biomaterials.2015.01.033 ↗
25. 10.1126/sciadv.abb762010.1126/sciadv.abb7620 ↗
26. 10.1038/s41596-018-0003-z10.1038/s41596-018-0003-z ↗
27. 10.1039/D3BM01146A10.1039/D3BM01146A ↗
28. 10.1016/j.stem.2014.06.00810.1016/j.stem.2014.06.008 ↗
29. 10.1177/002203452093283410.1177/0022034520932834 ↗
30. 10.1038/s41556-023-01284-910.1038/s41556-023-01284-9 ↗
31. 10.1038/s41467-023-37651-110.1038/s41467-023-37651-1 ↗
32. 10.1038/ncb357010.1038/ncb3570 ↗
33. 10.1016/j.stem.2018.11.02210.1016/j.stem.2018.11.022 ↗
34. 10.7554/eLife.1878210.7554/eLife.18782 ↗
35. 10.1016/j.stem.2019.11.00310.1016/j.stem.2019.11.003 ↗
36. 10.1038/s41467-021-23005-210.1038/s41467-021-23005-2 ↗
37. 10.7150/thno.3612010.7150/thno.36120 ↗
38. 10.1126/science.abi970210.1126/science.abi9702 ↗
39. 10.1002/jcp.2642910.1002/jcp.26429 ↗
40. 10.1021/acsnano.9b0048910.1021/acsnano.9b00489 ↗
41. 10.5582/bst.2014.0104710.5582/bst.2014.01047 ↗
42. 10.1021/acsnano.1c0828110.1021/acsnano.1c08281 ↗