DataVXACS Materials LettersPaper
journal article·2020-10-05

DNA Origami Nanostructures with Scaffolds Obtained from Rolling Circle Amplification

Mengyuan Xu, Chi Zhang, Cunjun Zhang, Yiling Zhao, Zhi Qi, Chunhai Fan, Jie Chao, Bryan Wei

ACS Materials Letters· Volume 2· Issue 10
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Source abstract

Abstract

As a guiding backbone of origami structural folding, the long single-stranded scaffold is the key enabler of all kinds of complex DNA nanostructures. However, the folding of most origami nanostructures depends heavily on very limited species of scaffolds. It is desirable to have a wider choice of scaffolds for the extended design space. Here we develop a new method based on rolling circle amplification to prepare scaffolds of custom lengths and sequences. We demonstrate that amplicons templated by viral genome and plasmid can serve as scaffolds to fold DNA origami nanostructures.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Bacteriophages and microbial interactions

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China

Center for Quantitative Biology, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

Key Laboratory for Organic Electronics and Information Displays (KLOEID), Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, School of Materials Science and Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210003, China

Funding

Peking University · Ministry of Science and Technology of the People's Republic of China · Tsinghua University · National Natural Science Foundation of China · Beijing Advanced Innovation Center for Structural Biology

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