DataVXAdvanced MaterialsPaper
journal article·2021-01

Voluntary‐Opsonization‐Enabled Precision Nanomedicines for Inflammation Treatment

Shuya Li, Min Li, Shaohu Huo, Qin Wang, Jing Chen, Shenggang Ding, Zhutian Zeng, Wenchao Zhou, Yucai Wang, Jun Wang

Advanced Materials· Volume 33· Issue 3
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Source abstract

Abstract

Abstract Nanomedicines that target specific blood cells represent an emerging strategy to improve drug biodistribution. However, the protein corona usually disrupts nanomedicine targeting to cells and tissues. Herein, instead of exploring synthetic methods to mitigate the impact of the protein corona, its natural interactions with blood cells are leveraged and turn the protein corona into an active ingredient in treating lung inflammation. It is discovered that molecularly engineered liposomes with inverse phosphocholine lipids rapidly enrich complement fragment iC3b by “voluntary opsonization,” which triggers neutrophil hijacking through complement receptor 3 phagocytosis. This neutrophil targeting is cell‐state dependent as only those activated by acute inflammation display efficient neutrophil reconstruction. The liposome‐loaded neutrophils migrate across the alveolar‐capillary barrier, accumulate in the inflamed lung parenchyma within hours, and release their payloads to kill the bacteria. This work shows that, in addition to biological cells, the protein corona can be a new platform for active and precision nanomedicine.
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Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Extracellular vesicles in disease · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Molecular Medicine Hefei National Laboratory for Physical Sciences at Microscale the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Sciences University of Science and Technology of China Hefei 230027 P. R. China

Department of Pediatrics the First Affiliated Hospital of Anhui Medical University Hefei 230022 P. R. China

Intelligent Pathology Institute the First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230001 P. R. China

Institutes for Life Sciences, School of Biomedical Sciences and Engineering National Engineering Research Center for Tissue Restoration and Reconstruction Key Laboratory of Biomedical Engineering of Guangdong Province South China University of Technology Guangdong 510006 P. R. China

Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005 P. R. China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Key Technologies Research and Development Program

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