journal article·2022-01Open access

The direct use of enzymatic biofuel cells as functional bioelectronics

Xinxin Xiao

eScience· Volume 2· Issue 1

Abstract

Enzymatic biofuel cells (EBFCs) are a subgroup of fuel cells that use enzymes as catalysts. EBFCs that utilize physiological substrates such as glucose or lactate are of great interest as implantable or wearable power sources to activate medical devices. This contribution introduces the working principles of EBFCs and summarizes recent progress in EBFC-enabled biosensors, pulse generators, and therapy. Biosensors with self-powered characteristic enjoy high selectivity, leading to potential “instrument-free” or “expensive-instrument-free” measurement. Autonomous pulse generation is based on the hybrid of EBFC and supercapacitor, which is promising for the application in medical related electrostimulation. By providing the direct electrical stimulation, or controllably releasing drug, EBFCs can also be used for self-powered therapeutic system. The further combination of self-powered sensing and treating enables EBFC as a possible platform of diagnostics and therapeutics. Future efforts can be focused on resolving the limited power density and lifetime of EBFC.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrochemical sensors and biosensors · Neuroscience and Neural Engineering · Supercapacitor Materials and Fabrication

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (89)

Show source-provided references
1. Enzymatic biofuel cells for implantable and microscale devices10.1021/cr020719k ↗
2. Tackling the challenges of enzymatic (Bio)Fuel cells10.1021/acs.chemrev.9b00115 ↗
3. Three-Dimensional sulfite oxidase bioanodes based on graphene functionalized carbon paper for sulfite/O2 biofuel cells10.1021/acscatal.9b01715 ↗
4. Bioelectrochemistry: I. Enzyme utilizing bio-fuel cell studies
5. Quo vadis, implanted fuel cell?10.1002/cplu.201600536 ↗
6. Characteristics of a miniature compartment-less Glucose−O2 biofuel cell and its operation in a living plant10.1021/ja0346328 ↗
7. Miniature biofuel cells10.1039/b313149a ↗
8. A glucose biofuel cell implanted in rats10.1371/journal.pone.0010476 ↗
9. Epidermal biofuel cells: energy harvesting from human perspiration10.1002/anie.201302922 ↗
10. Nanoporous gold-based biofuel cells on contact lenses10.1021/acsami.7b18708 ↗
11. Wearable bioelectronics: enzyme-based body-worn electronic devices10.1021/acs.accounts.8b00451 ↗
12. A passive perspiration biofuel cell: high energy return on investment10.1016/j.joule.2021.06.004 ↗
13. Biofuel cells-activation of micro- and macro-electronic devices10.1016/j.bioelechem.2017.09.002 ↗
14. Celebrating 50 years of the lithium power source for cardiac pacemakers10.1016/j.hrthm.2020.11.018 ↗
15. From "cyborg" lobsters to a pacemaker powered by implantable biofuel cells10.1039/C2EE23209J ↗
16. A pacemaker powered by an implantable biofuel cell operating under conditions mimicking the human blood circulatory system - battery not included10.1039/c3cp50929j ↗
17. Totally implantable enzymatic biofuel cell and brain stimulator operating in bird through wireless communication10.1016/j.bios.2020.112746 ↗
18. Self-Powered bioelectrochemical devices10.1016/j.coelec.2018.05.010 ↗
19. A symmetric supercapacitor/biofuel cell hybrid device based on enzyme-modified nanoporous gold: an autonomous pulse generator10.1016/j.bios.2016.11.012 ↗
20. A quasi-solid-state and self-powered biosupercapacitor based on flexible nanoporous gold electrodes10.1039/C8CC02555J ↗
21. A glucose/O2 fuel cell-based self-powered biosensor for probing a drug delivery model with self-diagnosis and self-evaluation10.1039/C8SC04019B ↗
22. Enzymatic biofuel cell: opportunities and intrinsic challenges in futuristic applications10.1002/aesr.202100031 ↗
23. Wearable biofuel cells: a review10.1002/elan.201600019 ↗
24. Implanted biofuel cells operating in vivo - methods, applications and perspectives - feature article10.1039/c3ee42126k ↗
25. Challenges for successful implantation of biofuel cells10.1016/j.bioelechem.2018.05.011 ↗
26. Recent advances on enzymatic glucose/oxygen and hydrogen/oxygen biofuel cells: achievements and limitations10.1016/j.jpowsour.2016.05.133 ↗
27. Electron transfer reactions in chemistry: theory and experiment (nobel lecture)10.1002/anie.199311113 ↗
28. Natural engineering principles of electron tunnelling in biological oxidation–reduction10.1038/46972 ↗
29. Long-range protein electron transfer observed at the single-molecule level: in situ mapping of redox-gated tunneling resonance10.1073/pnas.0508257102 ↗
30. Direct electrochemical enzyme electron transfer on electrodes modified by self-assembled molecular monolayers10.3390/catal10121458 ↗
31. O2 reduction in enzymatic biofuel cells10.1021/acs.chemrev.7b00220 ↗
32. There is no evidence to support literature claims of direct electron transfer (DET) for native glucose oxidase (GOx) at carbon nanotubes or graphene10.1016/j.jelechem.2017.06.021 ↗
33. Polymer coating for improved redox-polymer-mediated enzyme electrodes: a mini-review10.1016/j.elecom.2021.106931 ↗
34. Electron-conducting redox hydrogels: design, characteristics and synthesis10.1016/j.cbpa.2006.09.018 ↗
35. Redox polymers in electrochemical systems: from methods of mediation to energy storage10.1016/j.coelec.2019.03.003 ↗
36. Recent advances in surface chemistry of electrodes to promote direct enzymatic bioelectrocatalysis10.1016/j.coelec.2019.11.004 ↗
37. Direct electron transfer of fructose dehydrogenase immobilized on thiol-gold electrodes10.1016/j.electacta.2021.138946 ↗
38. Bilirubin oxidase oriented on novel type three-dimensional biocathodes with reduced graphene aggregation for biocathode10.1016/j.bios.2020.112500 ↗
39. How the intricate interactions between carbon nanotubes and two bilirubin oxidases control direct and mediated O2 reduction10.1021/acsami.6b07355 ↗
40. Buckypaper bioelectrodes: emerging materials for implantable and wearable biofuel cells10.1039/C8EE00330K ↗
41. Two-dimensional graphene paper supported flexible enzymatic fuel cells10.1039/C9NA00178F ↗
42. Development of graphene-based enzymatic biofuel cells: a minireview10.1016/j.bioelechem.2020.107537 ↗
43. Gold nanoparticles as electronic bridges for laccase-based biocathodes10.1021/ja307308j ↗
44. An overview of dealloyed nanoporous gold in bioelectrochemistry10.1016/j.bioelechem.2015.12.008 ↗
45. Analytical techniques for characterizing enzymatic biofuel cells10.1021/ac901243s ↗
46. A biofuel cell in non-aqueous solution10.1039/C5CC04888E ↗
47. Long tethers binding redox centers to polymer backbones enhance electron transport in enzyme “wiring” hydrogels10.1021/ja029510e ↗
48. Self-Powered enzyme-based biosensors10.1021/ja0167102 ↗
49. Self-Powered biosensors10.1021/acssensors.7b00818 ↗
50. Fuel cell-based self-powered electrochemical sensors for biochemical detection10.1016/j.nanoen.2019.04.056 ↗
51. Ultrasensitive self-powered cytosensor10.1016/j.nanoen.2015.03.035 ↗
52. Paper-Based electrochemical sensing platform with integral battery and electrochromic read-out10.1021/ac203457h ↗
53. Self-powered biosensor for ascorbic acid with a Prussian blue electrochromic display10.1016/j.bios.2013.11.033 ↗
54. Quantitative self-powered electrochromic biosensors10.1039/C6SC04469G ↗
55. Self-Powered bipolar electrochromic electrode arrays for direct displaying applications10.1021/acs.analchem.6b00054 ↗
56. Organic electrochromic timer for enzymatic skin patches10.1016/j.bios.2018.07.013 ↗
57. BioCapacitor—a novel category of biosensor10.1016/j.bios.2008.09.014 ↗
58. Wearable biosupercapacitor: harvesting and storing energy from sweat10.1002/adfm.202102915 ↗
59. A self-powered acetaldehyde sensor based on biofuel cell10.1021/ac302414a ↗
60. Self-Powered sensor for trace Hg2+ detection10.1021/ac2001884 ↗
61. Integrated self-powered microchip biosensor for endogenous biological cyanide10.1021/ac100274s ↗
62. Inhibition and activation of glucose oxidase bioanodes for use in a self-powered EDTA sensor10.1021/ac2011087 ↗
63. A three-dimensional origami-based immuno-biofuel cell for self-powered, low-cost, and sensitive point-of-care testing10.1039/c3cc47731b ↗
64. Enzymatic biofuel-cell-based self-powered biosensor integrated with DNA amplification strategy for ultrasensitive detection of single-nucleotide polymorphism10.1021/acs.analchem.9b02510 ↗
65. Highly sensitive and stable self-powered biosensing for exosomes based on dual metal-organic frameworks nanocarriers10.1016/j.bios.2020.112907 ↗
66. Trends in cardiac pacemaker batteries
67. Supercapacitor/Biofuel cell hybrids based on wired enzymes on carbon nanotube matrices: autonomous reloading after high power pulses in neutral buffered glucose solutions10.1039/C3EE43986K ↗
68. Self-charging electrochemical biocapacitor10.1002/celc.201300142 ↗
69. Supercapacitor/Biofuel cell hybrid device employing biomolecules for energy conversion and charge storage10.1016/j.bioelechem.2019.03.009 ↗
70. Pankratov · Angew. Chem. Int. Ed. · 2016 · 55 · 1543410.1002/anie.201607144 ↗
71. Biosupercapacitors for powering oxygen sensing devices10.1016/j.bioelechem.2015.04.012 ↗
72. Hybrid glucose/O2 biobattery and supercapacitor utilizing a pseudocapacitive dimethylferrocene redox polymer at the bioanode10.1021/acsenergylett.6b00225 ↗
73. Nano-biosupercapacitors enable autarkic sensor operation in blood10.1038/s41467-021-24863-6 ↗
74. Accelerated wound healing on skin by electrical stimulation with a bioelectric plaster10.1002/adhm.201700465 ↗
75. Transdermal electroosmotic flow generated by a porous microneedle array patch10.1038/s41467-021-20948-4 ↗
76. Enzyme catalyzed electrostimulation of human embryonic stem cell-derived cardiomyocytes influence contractility and synchronization10.1016/j.bej.2017.03.013 ↗
77. Performance of a glucose-reactive enzyme-based biofuel cell system for biomedical applications10.1038/s41598-019-47392-1 ↗
78. A self-powered “sense-act-treat” system that is based on a biofuel cell and controlled by boolean logic10.1002/anie.201107068 ↗
79. Biomolecular release triggered by glucose input-bioelectronic coupling of sensing and actuating systems10.1039/c3cc42027b ↗
80. A model system for targeted drug release triggered by biomolecular signals logically processed through enzyme logic networks10.1039/c3an02162a ↗
81. Biomolecular release from alginate-modified electrode triggered by chemical inputs processed through a biocatalytic cascade – integration of biomolecular computing and actuation10.1002/elan.201700810 ↗
82. Reconfigurable Implication and Inhibition Boolean logic gates based on NAD+-dependent enzymes: application to signal-controlled biofuel cells and molecule release
83. Anode-driven controlled release of cathodic fuel via pH response for smart enzymatic biofuel cell10.1016/j.isci.2020.101133 ↗
84. Organic transdermal iontophoresis patch with built-in biofuel cell10.1002/adhm.201400457 ↗
85. Enzymatic biofuel cells for self-powered, controlled drug release10.1021/jacs.0c05749 ↗
86. Antimicrobial enzymatic biofuel cells10.1039/D0CC07472A ↗
87. A novel self-powered time-temperature integrator (TTI) using modified biofuel cell for food quality monitoring10.1016/j.foodcont.2016.05.031 ↗
88. Artificial muscles powered by glucose10.1002/adma.201901677 ↗
89. Self-moisturizing smart contact lens employing electroosmosis10.1002/admt.201900889 ↗