DataVXACS Materials LettersPaper
journal article·2024-07-01

Tumor Microenvironment Stimuli Activatable Dendritic Mesoporous Cerium-Based Nanoplatform Boosting Synergistic Antitumor Efficacy

Lidan Hu, Yunfei Ying, Ao Wang, Tingting Li, Guangwei Zheng, Siyaqi Li, Jinhui Lin, Wu Jingkun, Qiang Luo, Peiyuan Wang

ACS Materials Letters· Volume 6· Issue 7
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Source abstract

Abstract

Obtaining a Ce-based nanocatalyst with high enough ROS production for the prevention of tumor cell proliferation is still a great challenge. Herein, we report a unique cerium nanocarrier with central divergent dendritic mesoporous channels, a high specific surface area, and more active cerium sites. ICG is loaded in the mesopores, and PEG motifs are grafted on the surface. This nanoplatform can efficaciously accumulate in the tumor regions, and the fascinating mesoporous nanocomposite can be triggered for massive Ce ion release under weak acid tumor microenvironments. Interestingly, upon NIR laser irradiation, high photothermal conversion efficiency of the nanoplatform is demonstrated. Then, the local thermal effect progressively potentiates ROS amplification. Both in vitro and in vivo studies demonstrate that our dendritic nanoplatform is able to efficaciously prevent tumorigenesis. All findings highlight the potency of tumor microenvironment stimuli activated dendritic Ce-based nanocomposites as chemodynamic nanoagents for malignant cancer ablating via a synergistic effect accompanied by NIR light illumination.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Dendrimers and Hyperbranched Polymers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Biochemistry and Molecular Biology, the Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical College, University of South China, Hengyang 421001, P. R. China

Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, P. R. China

Department of Neurosurgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, China

Funding

Natural Science Foundation of Hunan Province · Natural Science Foundation of Xiamen Municipality · Xiamen Municipal Bureau of Science and Technology · National Natural Science Foundation of China · Youth Science and Technology Innovation Project from Xiamen Ocean Development Bureau · Undergraduate Research and Innovation Project of South China University

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