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journal article·2024-09Open access

Piezoelectric Analgesia Blocks Cancer‐Induced Bone Pain

Yifei Yin, Peiran Zhao, Xianyun Xu, Bangguo Zhou, Jian Chen, Xingwu Jiang, Yanyan Liu, Yelin Wu, Wenwen Yue, Huixiong Xu, Wenbo Bu

Advanced Materials· Volume 36· Issue 36
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Source abstract

Abstract

Abstract The manipulation of cell surface receptors’ activity will open a new frontier for drug development and disease treatment. However, limited by the desensitization of drugs, effective physical intervention strategy remains challenging. Here, the controllable internalization of transient receptor potential vanilloid 1 (TRPV1) on neural cells by local piezoelectric field is reported. Single‐cell‐level local electric field is construct by synthesizing piezoelectric BiOIO3 nanosheets (BIONSs). Upon a mild ultrasound of 0.08 W cm−2, an electric field of 15.29 µV is generated on the surface of BIONSs, further inducing TRPV1 internalization in 5 min. The as‐downregulated TRPV1 expression results in the reduction of Ca2+ signal in a spinal neuron and the inhibition of the activity of wide range dynamic neurons, therefore effectively preventing the transmission of cancer‐induced bone pain (CIBP). This strategy not only charts a new course for CIBP alleviation, but also introduces a promising nanotechnology for regulating cell surface receptors, showing significant potential in neuropathological and receptor‐related diseases.
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Research context

Nanomaterials

OpenAlex topics: Pain Mechanisms and Treatments · Ion Channels and Receptors · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai 200032 China

Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment Shanghai 200072 China

National Clinical Research Center for Interventional Medicine Shanghai 200072 China

Center of Minimally Invasive Treatment for Tumor Department of Medical Ultrasound Shanghai Tenth People’s Hospital, School of Medicine Tongji University Shanghai 200072 China

Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 China

Department of Clinical Laboratory Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine Nanchang Jiangxi 330006 China

Funding

National Natural Science Foundation of China · Science and Technology Commission of Shanghai Municipality · Shanghai Municipal Health Commission

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