journal article·2024-05Open access

Early Diagnosis and Prognosis Prediction of Pancreatic Cancer Using Engineered Hybrid Core‐Shells in Laser Desorption/Ionization Mass Spectrometry

Juxiang Zhang, Fei Teng, Beiyuan Hu, Wanshan Liu, Yida Huang, Jiao Wu, Yuning Wang, Haiyang Su, Shouzhi Yang, Lumin Zhang, Lingchuan Guo, Zhe Lei, Meng Yan, Xiaoyu Xu, Ruimin Wang, Qingui Bao, Qiongzhu Dong, Jiang Long, Kun Qian

Advanced Materials· Volume 36· Issue 18

Abstract

Abstract Effective detection of bio‐molecules relies on the precise design and preparation of materials, particularly in laser desorption/ionization mass spectrometry (LDI‐MS). Despite significant advancements in substrate materials, the performance of single‐structured substrates remains suboptimal for LDI‐MS analysis of complex systems. Herein, designer Au@SiO2@ZrO2 core‐shell substrates are developed for LDI‐MS‐based early diagnosis and prognosis of pancreatic cancer (PC). Through controlling Au core size and ZrO2 shell crystallization, signal amplification of metabolites up to 3 orders is not only achieved, but also the synergistic mechanism of the LDI process is revealed. The optimized Au@SiO2@ZrO2 enables a direct record of serum metabolic fingerprints (SMFs) by LDI‐MS. Subsequently, SMFs are employed to distinguish early PC (stage I/II) from controls, with an accuracy of 92%. Moreover, a prognostic prediction scoring system is established with enhanced efficacy in predicting PC survival compared to CA19‐9 (p < 0.05). This work contributes to material‐based cancer diagnosis and prognosis.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Mass Spectrometry Techniques and Applications · Advanced Proteomics Techniques and Applications · Analytical chemistry methods development

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Systems Medicine for Cancer School of Biomedical Engineering Institute of Medical Robotics and Shanghai Academy of Experimental Medicine Shanghai Jiao Tong University Shanghai 200030 China

Division of Cardiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Department of Gastrointestinal Surgery Minhang Hospital Fudan University Shanghai 201199 China

Key Laboratory of Whole‐Period Monitoring and Precise Intervention of Digestive Cancer Shanghai Municipal Health Commission Minhang Hospital Fudan University Shanghai 201199 China

Department of Pancreatic Surgery Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200080 China

Department of Pathology The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Fosun Diagnostics (Shanghai) Co., Ltd Shanghai 200435 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Shanghai Municipal Health Commission · Shanghai Municipal Education Commission · Natural Science Foundation of Shanghai Municipality · School of Medicine, Shanghai Jiao Tong University · Innovative Research Team of High-level Local University in Shanghai · Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

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