journal article·2023-11

Threshold Modulative Artificial GABAergic Nociceptor

Geunyoung Kim, Younghyun Lee, Jae Bum Jeon, Woon Hyung Cheong, Woojoon Park, Hanchan Song, Kyung Min Kim

Advanced Materials· Volume 35· Issue 47
Publisher page

Abstract

Abstract Gamma‐aminobutyric acid (GABA) is a crucial inhibitory neurotransmitter of the central nervous system. It modifies the signal threshold of the nociceptor, allowing it to react to external stimuli in various circumstances. Thus, GABAergic behaviors are critical characteristics of adaptive behavior in life. Here, a threshold‐modulative artificial GABAergic nociceptor is reported for the first time at a Pt/Ti/Nb2O5−x/Al2O3−y/Pt/Ti (top to bottom) of the double charge trapping structure. The Al2O3−y layer contains deep defect states that function similarly to the GABA neurotransmitter in modulating the signal threshold. Meanwhile, the Nb2O5−x layer traps volatile charges and produces nociceptive behaviors. The combined dynamics of the two layers readily offer threshold‐modulative GABAergic nociceptive behaviors. Based on these GABAergic behaviors, a method of implementing hot‐ and cold‐sensitive thermoreceptors is demonstrated and shows its potential applications in advanced sensory devices.
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Research context

OpenAlex topics: Advanced Memory and Neural Computing · Conducting polymers and applications · Neuroscience and Neuropharmacology Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Funding

National Research Foundation of Korea

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