DataVXAdvanced MaterialsPaper
journal article·2024-08Open access

Additive Manufacturing of Biodegradable Molybdenum – From Powder to Vascular Stent

Dong Bian, Zhipei Tong, Gencheng Gong, He Huang, Liudang Fang, Hongtao Yang, Wenda Gu, Hui Yu, Yufeng Zheng

Advanced Materials· Volume 36· Issue 32
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Source abstract

Abstract

Abstract Magnesium, iron, and zinc‐based biodegradable metals are widely recognized as promising candidate materials for the next generation of bioresorbable stent (BVS). However, none of those metal BVSs are perfect at this stage. Here, a brand‐new BVS based on a novel biodegradable metal (Molybdenum, Mo) through additive manufacturing is developed. Nearly full‐dense and crack‐free thin‐wall Mo is directly manufactured through selective laser melting (SLM) with fine Mo powder. Systemic analyses considering the forming quality, wall‐thickness, microstructure, mechanical properties, and in vitro degradation behaviors are performed. Then, Mo‐based thin‐strut (≤ 100 µm) stents are successfully obtained through an optimized single‐track laser melting route. The SLMed thin‐wall Mo owns comparable strength to its Mg and Zn based counterparts (as‐drawn), while, it exhibits remarkable biocompatibility in vitro. Vessel related cells are well adhered and spread on SLMed Mo, and it exhibits a low risk of hemolysis and thrombus. The SLMed stent is compatible to vessel tissues in rat abdominal aorta, and it can provide sufficient support in an animal model as an extravascular stent. This work possibly opens a new era of manufacturing Mo‐based stents through additive manufacturing.
Source: crossref · Quality: baseline

Research context

BiomaterialsMaterials processing

OpenAlex topics: Magnesium Alloys: Properties and Applications · High Entropy Alloys Studies · Additive Manufacturing Materials and Processes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Medical Research Institute Department of Orthopedics Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou 510080 China

School of Medicine South China University of Technology Guangzhou 510006 China

School of Materials Science and Engineering Zhengzhou University Zhengzhou 450003 China

School of Engineering Medicine Beihang University Beijing 100191 China

Department of Cardiac Surgery Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou 510080 China

Guangzhou Key Laboratory of Spine Disease Prevention and Treatment Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510515 China

School of Materials Science and Engineering Peking University Beijing 100871 China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China

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