DataVXAdvanced MaterialsPaper
journal article·2023-10

Tuning the Organ Tropism of Polymersome for Spleen‐Selective Nanovaccine Delivery to Boost Cancer Immunotherapy

Wenxing Gu, Jingnan An, Yaxi Li, Yajie Yang, Shumin Wang, Hui Shan, Shenhua Li, Hui Li, Guoyong Liu, Kai Li, Yuxin Yin, Jing Mu, Xiaoyuan Chen

Advanced Materials· Volume 35· Issue 41
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Source abstract

Abstract

Abstract The past few decades have witnessed explosive development in drug delivery systems. However, in vivo delivery suffers from non‐specific distribution in non‐targeted organs or tissues, which may cause undesired side effects and even genotoxicity. Here, a general strategy that enables tuning the tropism of polymersomes for liver‐ and spleen‐selective delivery is reported. By using a library screening approach, spleen‐targeted polymersome PH9‐Aln‐8020 and liver‐targeted polymersome PA9‐ZP3‐5050 are identified accordingly. Meanwhile, the second near‐infrared (NIR‐II) fluorescence imaging allows for in vivo dynamic evaluation of their spatial and temporal accumulation in specific tissues. O ur findings indicate that both polymer composition and protein corona on the surface are essential to determine the in vivo fate of polymersomes and tendency for specific organs. Importantly, PH9‐Aln‐8020 is employed as a systemic nanocarrier to co‐deliver the antigen and adjuvant, which remarkably boost splenic immune responses in acute myeloid leukemia, melanoma, and melanoma lung metastasis mouse models. This study may open a new frontier for polymersomes in organ‐selective delivery and other biomedical applications.
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Research context

PolymersNanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Precision Medicine Peking University Shenzhen Hospital Shenzhen 518036 P. R. China

Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering Biomedical Engineering Yong Loo Lin School of Medicine College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced Biomaterials Department of Biomedical Engineering Southern University of Science and Technology Shenzhen 518055 P. R. China

The First Affiliated Hospital of Soochow University Institute of Blood and Marrow Transplantation of Soochow University Collaborative Innovation Center of Hematology Soochow University Suzhou 215123 P. R. China

Funding

National Natural Science Foundation of China · Guangdong Provincial Department of Science and Technology

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