journal article·2025-08

Advances in Biocompatible Metal‐Organic Frameworks for Biomedical Applications

Zhe Li, Minghong He, Yuanbo Wang, Jing Yang, Yuexin He, Xingyu Chen, Weikang Zhang, Hao Wu, Renjie Chai, Bo Wang

Advanced Materials· Volume 37· Issue 33
Publisher page

Abstract

Abstract Metal‐organic frameworks (MOFs) have many excellent properties, such as adjustable pore size and volume, clear active sites, high specific surface area and other inherent characteristics. It makes them suitable for various applications, including disease treatment, imaging, and sensing. The article reviews several types of biocompatible MOFs and their recent advances in biomedical applications, especially in disease therapy. Finally, the challenges to be overcome in this field and the application prospects of this material in biomedicine are prospected.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurology Aerospace Center Hospital School of Life Science Beijing Institute of Technology Beijing 100081 P. R. China

Key Laboratory of Cluster Science Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Frontiers Science Center for High Energy Material Advanced Technology Research Institute (Jinan) School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China

Aerospace Center Hospital Peking University Aerospace Clinical College Beijing 100049 P. R. China

Department of Neurosurgery Xuanwu Hospital Capital Medical University Beijing 100069 P. R. China

State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Medicine Advanced Institute for Life and Health Jiangsu Province High‐Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 P. R. China

Co‐Innovation Center of Neuroregeneration Nantong University Nantong 226001 P. R. China

Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu 610072 P. R. China

Southeast University Shenzhen Research Institute Shenzhen 518063 P. R. China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province · Science and Technology Department of Sichuan Province · Natural Science Foundation of Beijing Municipality

References (100+)

Show source-provided references
1. 10.1038/s41467-025-56257-310.1038/s41467-025-56257-3 ↗
2. 10.1016/j.mtbio.2025.10154010.1016/j.mtbio.2025.101540 ↗
3. 10.1021/acsnano.2c1244810.1021/acsnano.2c12448 ↗
4. 10.1038/s41392-024-01889-y10.1038/s41392-024-01889-y ↗
5. 10.2217/nnm-2021-025510.2217/nnm-2021-0255 ↗
6. 10.1038/s41467-024-54810-010.1038/s41467-024-54810-0 ↗
7. 10.1016/j.addr.2013.05.01210.1016/j.addr.2013.05.012 ↗
8. 10.1039/D0NR03957H10.1039/D0NR03957H ↗
9. Parvin N. · T. K. Mandal · 2025 · 16 · 419
10. 10.1016/j.jddst.2023.10428510.1016/j.jddst.2023.104285 ↗
11. 10.1039/D3NR01723K10.1039/D3NR01723K ↗
12. He Q. Q. · Small · 2023 · 19
13. 10.1093/rb/rbad09710.1093/rb/rbad097 ↗
14. 10.1021/acsami.8b1692010.1021/acsami.8b16920 ↗
15. 10.1016/j.chempr.2023.09.01610.1016/j.chempr.2023.09.016 ↗
16. 10.1021/acsami.1c2475910.1021/acsami.1c24759 ↗
17. 10.1002/celc.20170093110.1002/celc.201700931 ↗
18. 10.1039/D3TB03047D10.1039/D3TB03047D ↗
19. 10.3390/nano1315219410.3390/nano13152194 ↗
20. 10.1002/anie.20231507510.1002/anie.202315075 ↗
21. 10.1016/j.jcat.2024.11584310.1016/j.jcat.2024.115843 ↗
22. 10.1016/j.addr.2023.11504210.1016/j.addr.2023.115042 ↗
23. 10.1039/D0CS01030H10.1039/D0CS01030H ↗
24. 10.1039/D0CS00178C10.1039/D0CS00178C ↗
25. 10.1021/acsnano.0c0961710.1021/acsnano.0c09617 ↗
26. 10.1021/acs.accounts.3c0078810.1021/acs.accounts.3c00788 ↗
27. 10.1002/cey2.50110.1002/cey2.501 ↗
28. 10.1016/j.ccr.2021.21432710.1016/j.ccr.2021.214327 ↗
29. 10.1038/s43586-024-00320-810.1038/s43586-024-00320-8 ↗
30. 10.1016/j.colsurfb.2022.11305810.1016/j.colsurfb.2022.113058 ↗
31. 10.1002/adfm.20220629410.1002/adfm.202206294 ↗
32. 10.1021/acsnano.3c1054110.1021/acsnano.3c10541 ↗
33. 10.1002/wnan.187410.1002/wnan.1874 ↗
34. 10.1016/j.matt.2024.10194810.1016/j.matt.2024.101948 ↗
35. 10.1016/j.tifs.2020.08.00410.1016/j.tifs.2020.08.004 ↗
36. 10.1002/chem.20140538010.1002/chem.201405380 ↗
37. 10.1016/j.cej.2023.14440010.1016/j.cej.2023.144400 ↗
38. 10.1039/D1CS00918D10.1039/D1CS00918D ↗
39. 10.1007/s10238-024-01302-610.1007/s10238-024-01302-6 ↗
40. 10.1016/j.ijpharm.2024.12396810.1016/j.ijpharm.2024.123968 ↗
41. 10.1016/j.jtv.2023.01.00710.1016/j.jtv.2023.01.007 ↗
42. 10.1161/CIRCRESAHA.123.32361710.1161/CIRCRESAHA.123.323617 ↗
43. 10.1016/j.jece.2024.11423310.1016/j.jece.2024.114233 ↗
44. 10.1021/acsabm.4c0042710.1021/acsabm.4c00427 ↗
45. 10.2147/IJN.S46248010.2147/IJN.S462480 ↗
46. 10.3390/met1309151110.3390/met13091511 ↗
47. 10.1007/s00210-023-02707-y10.1007/s00210-023-02707-y ↗
48. 10.1073/pnas.060243910310.1073/pnas.0602439103 ↗
49. 10.1016/j.cej.2020.12791410.1016/j.cej.2020.127914 ↗
50. 10.1016/j.jiec.2021.09.02910.1016/j.jiec.2021.09.029 ↗
51. 10.1016/j.ccr.2023.21546410.1016/j.ccr.2023.215464 ↗
52. Sun Y. · Adv. Mater. · 2024 · 36 · 15
53. 10.1007/s40843-024-2909-910.1007/s40843-024-2909-9 ↗
54. 10.1186/s12951-024-02398-410.1186/s12951-024-02398-4 ↗
55. 10.1016/j.jcis.2024.01.12910.1016/j.jcis.2024.01.129 ↗
56. 10.1016/j.fochx.2024.10198310.1016/j.fochx.2024.101983 ↗
57. 10.1007/s13205-024-04145-w10.1007/s13205-024-04145-w ↗
58. 10.1016/j.ijbiomac.2024.13796610.1016/j.ijbiomac.2024.137966 ↗
59. 10.1007/s40820-024-01353-010.1007/s40820-024-01353-0 ↗
60. 10.1016/j.snb.2024.13623910.1016/j.snb.2024.136239 ↗
61. 10.1007/s12598-024-03008-w10.1007/s12598-024-03008-w ↗
62. 10.1021/acs.analchem.4c0343410.1021/acs.analchem.4c03434 ↗
63. 10.1080/09205063.2024.241006010.1080/09205063.2024.2410060 ↗
64. 10.1007/s13346-024-01714-710.1007/s13346-024-01714-7 ↗
65. 10.1016/j.ijbiomac.2024.13566010.1016/j.ijbiomac.2024.135660 ↗
66. 10.1021/acsami.4c0816910.1021/acsami.4c08169 ↗
67. 10.1016/j.ijbiomac.2024.13533810.1016/j.ijbiomac.2024.135338 ↗
68. 10.1016/j.colsurfa.2024.13522710.1016/j.colsurfa.2024.135227 ↗
69. 10.3390/ijms2517929210.3390/ijms25179292 ↗
70. 10.3389/fchem.2024.145267010.3389/fchem.2024.1452670 ↗
71. 10.1016/j.jconrel.2024.08.01110.1016/j.jconrel.2024.08.011 ↗
72. 10.1021/acsomega.4c0244610.1021/acsomega.4c02446 ↗
73. 10.1021/acsami.4c0230110.1021/acsami.4c02301 ↗
74. 10.1038/s41598-024-57664-010.1038/s41598-024-57664-0 ↗
75. 10.1016/j.inoche.2024.11322610.1016/j.inoche.2024.113226 ↗
76. 10.1016/j.bioadv.2024.21411810.1016/j.bioadv.2024.214118 ↗
77. 10.1002/bab.268910.1002/bab.2689 ↗
78. 10.1039/D4RA05460A10.1039/D4RA05460A ↗
79. 10.1016/j.matlet.2024.13596110.1016/j.matlet.2024.135961 ↗
80. 10.1007/s11426-023-1875-710.1007/s11426-023-1875-7 ↗
81. 10.1016/j.cub.2021.03.05410.1016/j.cub.2021.03.054 ↗
82. 10.1002/anie.20210896110.1002/anie.202108961 ↗
83. 10.1155/2022/541837610.1155/2022/5418376 ↗
84. 10.4067/S0717-9502202200010001010.4067/S0717-95022022000100010 ↗
85. 10.1002/cmdc.20240006010.1002/cmdc.202400060 ↗
86. Lu X. F. · Adv. Sci. · 2024 · 11
87. 10.3389/fcimb.2014.0000310.3389/fcimb.2014.00003 ↗
88. 10.1016/j.actbio.2020.09.04410.1016/j.actbio.2020.09.044 ↗
89. 10.1016/j.jinorgbio.2021.11159910.1016/j.jinorgbio.2021.111599 ↗
90. 10.3390/pharmaceutics1503082210.3390/pharmaceutics15030822 ↗
91. 10.1016/j.ijhydene.2012.04.10510.1016/j.ijhydene.2012.04.105 ↗
92. 10.1002/smll.20190518410.1002/smll.201905184 ↗
93. 10.1016/j.cej.2022.13596410.1016/j.cej.2022.135964 ↗
94. 10.1021/acs.cgd.0c0144710.1021/acs.cgd.0c01447 ↗
95. 10.1016/j.actbio.2024.05.00810.1016/j.actbio.2024.05.008 ↗
96. 10.1016/j.cej.2024.15854610.1016/j.cej.2024.158546 ↗
97. 10.1039/C9DT00791A10.1039/C9DT00791A ↗
98. 10.1016/j.jssc.2019.04.01610.1016/j.jssc.2019.04.016 ↗
99. 10.1038/s41580-023-00648-110.1038/s41580-023-00648-1 ↗
100. 10.1161/CIRCRESAHA.122.32166710.1161/CIRCRESAHA.122.321667 ↗