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journal article·2024-10Open access

Implantable Microneedle‐Mediated Eradication of Postoperative Tumor Foci Mitigates Glioblastoma Relapse

Yulin Zhang, Zezheng Fang, Zejuan Liu, Kaiyan Xi, Yi Zhang, Dawang Zhao, Fan Feng, Humin Geng, Minglu Liu, Jingzhao Lou, Chen Chen, Yanmin Zhang, Zimei Wu, Feng Xu, Xinyi Jiang, Shilei Ni

Advanced Materials· Volume 36· Issue 40
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Abstract

Abstract Glioblastoma multiforme (GBM) remains incurable despite multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin (2–3 cm) of the initial resected lesion due to the unreachable residual cancerous cells. Here, a completely biodegradable microneedle for surgical cavity delivery glioblastoma‐associated macrophages (GAMs)‐activating immune nano‐stimulator that mitigates glioblastoma relapse is reported. The residual tumor lesion‐directed biocompatible microneedle releases the nano‐stimulator and toll‐like receptor 9 agonist in a controlled manner until the microneedles completely degrade over 1 week, efferently induce in situ phonotypic shifting of GAMs from anti‐ to pro‐inflammatory and the tumor recurrence is obviously inhibited. The implantable microneedles offer a significant improvement over conventional transdermal ones, as they are 100% degradable, ensuring safe application within surgical cavities. It is also revealed that the T cells are recruited to the tumor niche as the GAMs initiate anti‐tumor response and eradicate residual GBM cells. Taken together, this work provides a potential strategy for immunomodulating the postoperative tumor niche to mitigate tumor relapse in GBM patients, which may have broad applications in other malignancies with surgical intervention.
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Research context

Biomaterials

OpenAlex topics: 3D Printing in Biomedical Research · Advancements in Transdermal Drug Delivery · Advanced Fluorescence Microscopy Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery Qilu Hospital and Institute of Brain and Brain‐Inspired Science Cheeloo College of Medicine Shandong University 107 Wenhua Xi Road Jinan Shandong 250012 China

Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics NMPA Key laboratory for technology Research and evaluation of drug Products and Key laboratory of chemical Biology Ministry of education School of Pharmaceutical Sciences Cheeloo College of Medicine Shandong University 44 Wenhua Xi Road Jinan Shandong 250012 China

Department of Emergency Medicine Chest Pain Center Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong University Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary‐Cerebral Resuscitation Research of Shandong Province NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug Shandong Provincial Engineering Laboratory for...

Department of Orthopedics Qilu Hospital of Shandong University Cheeloo College of Medicine Shandong University 107 Wenhua Xi Road Jinan Shandong 250012 China

Bellastem Biotechnology Limited High‐Tech incubator Intersection of Liquan Street and Gaoxin Er Road Gaomi Shandong 261500 China

Key Laboratory of the Ministry of Education for Experimental Teratology Shandong Provincial Key Laboratory of Mental Disorders Department of Histology and Embryology Cheeloo College of Medicine Shandong University 44 Wenhua Xi Road Jinan Shandong 250012 China

Faculty of Medicine and Health Sciences School of Pharmacy University of Auckland Auckland 1023 New Zealand

Funding

National Natural Science Foundation of China · Natural Science Foundation of Shandong Province · China Postdoctoral Science Foundation · Taishan Scholar Foundation of Shandong Province

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