Freestanding Hydrogen‐Bonded Organic Framework Membrane for Efficient Wound Healing

Abstract Hydrogen‐bonded organic frameworks (HOFs) are emerging as multifunctional materials with exceptional biocompatibility, abundant active sites, and tunable porosity, which are highly beneficial for advanced wound care. However, a significant challenge involves transforming pristine HOFs powders into lightweight, ultrathin, freestanding membranes compatible with soft biological systems. Herein, the study successfully develops shape‐adaptive HOF‐based matrix membranes (HMMs) using a polymer‐assisted liquid‐air interface technique. The HMMs conform seamlessly to tissues of different sizes and shapes, effectively stopping bleeding, and provide high water‐vapor permeability. Notably, both in vitro and in vivo studies with mice wound models demonstrated that these tissue‐conformable HMMs significantly accelerate wound healing by modulating the inflammatory environment of the injured tissue and promoting rapid re‐epithelialization. Furthermore, RNA‐seq analysis and mechanistic studies revealed that HMMs effectively reduce inflammation and facilitate the tissue transition from the proliferative stage to the remodeling stage of skin development. This work not only opens up new avenues for advanced wound care materials but also establishes a foundation for hybridizing HOFs with polymers for a wide range of potential applications.