DataVXAdvanced MaterialsPaper
journal article·2023-05Open access

Engineering and Development of a Tissue Model for the Evaluation of Microneedle Penetration Ability, Drug Diffusion, Photothermal Activity, and Ultrasound Imaging: A Promising Surrogate to Ex Vivo and In Vivo Tissues

Pooyan Makvandi, Majid Shabani, Navid Rabiee, Qonita Kurnia Anjani, Aziz Maleki, Ehsan Nazarzadeh Zare, Akmal Hidayat Bin Sabri, Daniele De Pasquale, Maria Koskinopoulou, Esmaeel Sharifi, Rossella Sartorius, Mohammad Seyedhamzeh, Shayesteh Bochani, Ikue Hirata, Ana Cláudia Paiva‐Santos, Leonardo S. Mattos, Ryan F. Donnelly, Virgilio Mattoli

Advanced Materials· Volume 35· Issue 18
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Source abstract

Abstract

Abstract Driven by regulatory authorities and the ever‐growing demands from industry, various artificial tissue models have been developed. Nevertheless, there is no model to date that is capable of mimicking the biomechanical properties of the skin whilst exhibiting the hydrophilicity/hydrophobicity properties of the skin layers. As a proof‐of‐concept study, tissue surrogates based on gel and silicone are fabricated for the evaluation of microneedle penetration, drug diffusion, photothermal activity, and ultrasound bioimaging. The silicone layer aims to imitate the stratum corneum while the gel layer aims to mimic the water‐rich viable epidermis and dermis present in in vivo tissues. The diffusion of drugs across the tissue model is assessed, and the results reveal that the proposed tissue model shows similar behavior to a cancerous kidney. In place of typical in vitro aqueous solutions, this model can also be employed for evaluating the photoactivity of photothermal agents since the tissue model shows a similar heating profile to skin of mice when irradiated with near‐infrared laser. In addition, the designed tissue model exhibits promising results for biomedical applications in optical coherence tomography and ultrasound imaging. Such a tissue model paves the way to reduce the use of animals testing in research whilst obviating ethical concerns.
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Research context

OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Optical Coherence Tomography Applications · Ultrasound and Hyperthermia Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Centre for Materials Interfaces Istituto Italiano di Tecnologia viale Rinaldo Piaggio 34 Pontedera 56025 Pisa Italy

School of Engineering Institute for Bioengineering The University of Edinburgh Edinburgh EH9 3JL UK

The BioRobotics Institute Scuola Superiore Sant'Anna Pontedera 56025 Pisa Italy

Bioinspired Soft Robotics Laboratory Istituto Italiano di Tecnologia 16163 Genova Italy

Centre for Molecular Medicine and Innovative Therapeutics Murdoch University Perth WA 6150 Australia

School of Engineering Macquarie University Sydney New South Wales 2109 Australia

School of Pharmacy Queen's University Belfast 97 Lisburn Road Belfast BT9 7BL UK

Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC) Department of Pharmaceutical Nanotechnology School of Pharmacy Zanjan University of Medical Sciences Zanjan 45139–56184 Iran

School of Chemistry Damghan University Damghan 36716–45667 Iran

Department of Advanced Robotics (ADVR) Istituto Italiano di Tecnologia 16163 Genova Italy

Cancer Research Center Hamadan University of Medical Sciences Hamadan 65178‐38736 Iran

Institute of Biochemistry and Cell Biology (IBBC) National Research Council (CNR) 80131 Naples Italy

Department of Pharmaceutical Technology Faculty of Pharmacy of the University of Coimbra University of Coimbra Azinhaga Sta. Comba Coimbra 3000–548 Portugal

LAQV REQUIMTE Department of Pharmaceutical Technology Faculty of Pharmacy of the University of Coimbra University of Coimbra Azinhaga Sta. Comba Coimbra 3000–548 Portugal

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