Targeted ROS Scavenging for Disease Therapies Using Nanomaterials
Source abstract
Abstract
Abstract Reactive oxygen species (ROS) are essential by‐products of cellular metabolism and serve as key mediators in cell signaling and homeostasis. Excessive ROS production is associated with cellular damage and various diseases. Therefore, targeted ROS scavenging may enhance therapeutic efficacy and minimize side effects. With significant progress in nanotechnology, various nanomaterials with targeted ROS‐scavenging properties have been developed to modulate ROS levels in biological microenvironments. In this review, the mechanisms underlying ROS generation and elimination in humans and in ROS‐related diseases are first outlined. The latest advancements in ROS‐scavenging nanomaterials, particularly their mechanisms and composition‐based classifications, are then focused on. Strategies for improving the targeting ability of ROS‐scavenging nanomaterials and their application in the therapeutics of ROS‐induced diseases such as Alzheimer's disease, rheumatoid arthritis, acute kidney injury, diabetic wounds, and cancer are highlighted. Finally, the challenges faced by ROS‐targeted nanotherapeutics are discussed, and possible alternatives to accelerate their clinical translation are proposed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Sulfur Compounds in Biology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
CAS Key Laboratory for Nano‐Bio Interface Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 China
Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore Singapore 119074 Singapore
Department of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore Singapore 117575 Singapore
Department of Biomedical Engineering College of Design and Engineering National University of Singapore Singapore 117575 Singapore
State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China
Department of Pharmacy and Pharmaceutical Sciences Faculty of Science National University of Singapore Singapore 117544 Singapore
Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore
Funding
National University of Singapore · National Medical Research Council · National Research Foundation · National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province
References (100+)
Show source-provided references
1. 10.1021/acs.chemrev.8b0062610.1021/acs.chemrev.8b00626 ↗
2. 10.1152/physrev.00026.201310.1152/physrev.00026.2013 ↗
3. 10.1038/s41580-020-0230-310.1038/s41580-020-0230-3 ↗
4. 10.1155/2019/508084310.1155/2019/5080843 ↗
5. 10.1038/s41573-021-00233-110.1038/s41573-021-00233-1 ↗
6. 10.1038/s41580-022-00456-z10.1038/s41580-022-00456-z ↗
7. 10.1016/j.cub.2014.03.03410.1016/j.cub.2014.03.034 ↗
8. 10.1016/j.cell.2022.06.00310.1016/j.cell.2022.06.003 ↗
9. 10.1039/D1CS00044F10.1039/D1CS00044F ↗
10. 10.3390/cells910231410.3390/cells9102314 ↗
11. 10.1016/j.molcel.2021.08.01810.1016/j.molcel.2021.08.018 ↗
12. 10.1155/2022/556375910.1155/2022/5563759 ↗
13. 10.1002/anie.20200045110.1002/anie.202000451 ↗
14. 10.3389/fphar.2023.114741410.3389/fphar.2023.1147414 ↗
15. 10.1016/j.cej.2024.15175610.1016/j.cej.2024.151756 ↗
16. 10.1038/s41573-020-0090-810.1038/s41573-020-0090-8 ↗
17. 10.1021/acsami.1c1826110.1021/acsami.1c18261 ↗
18. 10.1186/s13045-023-01512-710.1186/s13045-023-01512-7 ↗
19. 10.1038/s41580-023-00645-410.1038/s41580-023-00645-4 ↗
20. 10.1016/j.addr.2021.11387010.1016/j.addr.2021.113870 ↗
21. 10.1002/adfm.20230513310.1002/adfm.202305133 ↗
22. 10.1186/s12951-025-03322-010.1186/s12951-025-03322-0 ↗
23. 10.1021/acsnano.3c0325210.1021/acsnano.3c03252 ↗
24. 10.1016/j.cej.2024.15507310.1016/j.cej.2024.155073 ↗
25. 10.1002/adfm.20240465810.1002/adfm.202404658 ↗
26. 10.1016/j.jconrel.2024.12.02410.1016/j.jconrel.2024.12.024 ↗
27. 10.1021/acsami.9b1898610.1021/acsami.9b18986 ↗
28. 10.1002/advs.20210050510.1002/advs.202100505 ↗
29. 10.1002/anie.20210103310.1002/anie.202101033 ↗
30. 10.1016/j.cej.2021.12928410.1016/j.cej.2021.129284 ↗
31. 10.1016/j.mtbio.2023.10054410.1016/j.mtbio.2023.100544 ↗
32. 10.1002/adhm.20230264010.1002/adhm.202302640 ↗
33. 10.1038/s41467-020-16544-710.1038/s41467-020-16544-7 ↗
34. 10.1016/j.apmt.2021.10110910.1016/j.apmt.2021.101109 ↗
35. 10.1016/j.biomaterials.2021.12076610.1016/j.biomaterials.2021.120766 ↗
36. 10.1021/acs.biomac.9b0017410.1021/acs.biomac.9b00174 ↗
37. 10.1021/acsnano.2c0920210.1021/acsnano.2c09202 ↗
38. 10.1002/adma.20230655210.1002/adma.202306552 ↗
39. 10.1126/sciadv.abj237210.1126/sciadv.abj2372 ↗
40. 10.1021/acsnano.2c0555810.1021/acsnano.2c05558 ↗
41. 10.1039/C5CC01779C10.1039/C5CC01779C ↗
42. 10.1186/s12951-020-00744-w10.1186/s12951-020-00744-w ↗
43. 10.1016/j.apsb.2022.09.01910.1016/j.apsb.2022.09.019 ↗
44. 10.1002/anie.20240388010.1002/anie.202403880 ↗
45. 10.1016/j.chempr.2020.10.02510.1016/j.chempr.2020.10.025 ↗
46. 10.1038/s41551-018-0317-810.1038/s41551-018-0317-8 ↗
47. 10.1021/jacs.2c1032310.1021/jacs.2c10323 ↗
48. 10.1021/acsnano.2c0399110.1021/acsnano.2c03991 ↗
49. 10.1021/acs.nanolett.1c0104410.1021/acs.nanolett.1c01044 ↗
50. 10.1002/adfm.20240278110.1002/adfm.202402781 ↗
51. 10.1016/j.addr.2012.05.00810.1016/j.addr.2012.05.008 ↗
52. 10.1021/acsnano.3c0655110.1021/acsnano.3c06551 ↗
53. 10.1007/s40820-021-00674-810.1007/s40820-021-00674-8 ↗
54. Zhou S. · Chem. Rev. · 2024 · 500
55. 10.1021/acsami.0c1963310.1021/acsami.0c19633 ↗
56. 10.1016/j.jconrel.2025.11368310.1016/j.jconrel.2025.113683 ↗
57. 10.1021/acsnano.4c1570510.1021/acsnano.4c15705 ↗
58. 10.1016/j.bioactmat.2022.12.02110.1016/j.bioactmat.2022.12.021 ↗
59. 10.1002/adfm.20240941610.1002/adfm.202409416 ↗
60. 10.1002/adma.20241535310.1002/adma.202415353 ↗
61. 10.1016/j.biomaterials.2022.12143710.1016/j.biomaterials.2022.121437 ↗
62. 10.1038/nnano.2012.26410.1038/nnano.2012.264 ↗
63. 10.1038/s41565-019-0406-110.1038/s41565-019-0406-1 ↗
64. 10.1021/nn300291r10.1021/nn300291r ↗
65. 10.1038/s41565-025-01907-210.1038/s41565-025-01907-2 ↗
66. 10.1002/adfm.20200223410.1002/adfm.202002234 ↗
67. 10.1038/s41467-020-19061-910.1038/s41467-020-19061-9 ↗
68. 10.1016/j.nantod.2020.10092510.1016/j.nantod.2020.100925 ↗
69. 10.1002/adhm.20230063210.1002/adhm.202300632 ↗
70. 10.1021/jacs.3c0704810.1021/jacs.3c07048 ↗
71. 10.7150/thno.5191210.7150/thno.51912 ↗
72. 10.1021/acsnano.1c0720510.1021/acsnano.1c07205 ↗
73. 10.1002/adhm.20230255610.1002/adhm.202302556 ↗
74. 10.1021/jacs.4c1216610.1021/jacs.4c12166 ↗
75. 10.1002/adma.20200156610.1002/adma.202001566 ↗
76. 10.1002/anie.20220110110.1002/anie.202201101 ↗
77. 10.1002/anie.20241668610.1002/anie.202416686 ↗
78. 10.1021/acs.chemrev.5b0048210.1021/acs.chemrev.5b00482 ↗
79. 10.1021/jacs.8b1185610.1021/jacs.8b11856 ↗
80. 10.1002/advs.20240226710.1002/advs.202402267 ↗
81. 10.1038/ncomms630110.1038/ncomms6301 ↗
82. 10.1002/anie.20160086810.1002/anie.201600868 ↗
83. 10.1038/s41565-019-0527-610.1038/s41565-019-0527-6 ↗
84. 10.1002/smll.20150391910.1002/smll.201503919 ↗
85. 10.1016/j.fmre.2022.07.00210.1016/j.fmre.2022.07.002 ↗
86. 10.1038/s41467-020-20275-010.1038/s41467-020-20275-0 ↗
87. 10.1126/sciadv.adh782810.1126/sciadv.adh7828 ↗
88. 10.1016/j.bioactmat.2021.08.01210.1016/j.bioactmat.2021.08.012 ↗
89. 10.1021/acsnano.3c0751710.1021/acsnano.3c07517 ↗
90. 10.1002/adma.20240917610.1002/adma.202409176 ↗
91. 10.1021/acs.nanolett.1c0445410.1021/acs.nanolett.1c04454 ↗
92. 10.1016/j.nantod.2020.10102710.1016/j.nantod.2020.101027 ↗
93. 10.1021/acsami.1c0668710.1021/acsami.1c06687 ↗
94. 10.1186/s12951-022-01495-610.1186/s12951-022-01495-6 ↗
95. 10.1002/adfm.20210489210.1002/adfm.202104892 ↗
96. 10.1021/acs.nanolett.9b0503510.1021/acs.nanolett.9b05035 ↗
97. 10.1016/j.bioactmat.2021.01.01610.1016/j.bioactmat.2021.01.016 ↗
98. 10.1186/s12951-021-00897-210.1186/s12951-021-00897-2 ↗
99. 10.1021/acsnano.2c0283210.1021/acsnano.2c02832 ↗
100. 10.1186/s12951-021-01006-z10.1186/s12951-021-01006-z ↗