Directional Freeze‐Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal–Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects
Source abstract
Abstract
Abstract Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected bone defects. Its recurrent and resistant nature, high incidence rate, long‐term hospitalization, and high medical costs have driven the efforts of the scientific community to develop new therapies to improve the situation. Considering the complex microenvironment and persistent mechanisms mediated by resistant bacteria, it is crucial to develop an implant with enhanced osseointegration and sustained and effective infection clearance effects. Here, a positively charged quaternized chitosan (QCS) coated gallium‐based metal–organic framework (GaMOF) is designed, to capture the antibiotic‐resistant bacteria (Methicillin‐resistant Staphylococcus aureus , MRSA) as a “captor”, and rejuvenate Methicillin (Me) via disturbing the tricarboxylic acid (TCA) cycle. Then, a radially oriented porous cryogel loaded with the Me and QCSGaMOF is fabricated by the directional freeze‐casting method. The oriented porous structure has an enhanced osseointegration effect by guiding the ingrowth of osteogenic cells. In vitro and in vivo experiments prove the advantages of as‐prepared Me/QCSGa‐MOF@Cryogel in combating resistant bacteria and guiding bone regeneration in infected bone defects.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Orthopedic Infections and Treatments · Nanoplatforms for cancer theranostics · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China
Department of Bone and Joint Surgery Department of Orthopedics Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 P. R. China
Department of Orthopedics The First Affiliated Hospital Zhejiang University School of Medicine 79 Qingchun Rd Hangzhou 310003 P. R. China
Department of Orthopedic Surgery Xuzhou Central Hospital Xuzhou Clinical School of Xuzhou Medical University 199Jiefang South Road Xuzhou 221009 P. R. China
School of Pharmacy The University of Sydney Sydney NSW 2006 Australia
Shanghai Institute of Precision Medicine Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200125 P. R. China
Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China
Funding
National Natural Science Foundation of China · China Postdoctoral Science Foundation
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