journal article·2024-09Open access

Interstitial Optical Fiber‐Mediated Multimodal Phototheranostics Based on an Aggregation‐Induced NIR‐II Emission Luminogen for Orthotopic Breast Cancer Treatment

Wenguang Zhang, Miaomiao Kang, Xue Li, Hao Yang, Zhijun Zhang, Zhuorong Li, Yibin Zhang, Miaozhuang Fan, Changrui Liao, Chengbo Liu, Gaixia Xu, Dong Wang, Zhourui Xu, Ben Zhong Tang

Advanced Materials· Volume 36· Issue 38

Abstract

Abstract One‐for‐all phototheranostics based on a single molecule is recognized as a convenient approach for cancer treatment, whose efficacy relies on precise lesion localization through multimodal imaging, coupled with the efficient exertion of phototherapy. To unleash the full potential of phototheranostics, advancement in both phototheranostic agents and light delivery methods is essential. Herein, an integrated strategy combining a versatile molecule featuring aggregation‐induced emission, namely tBuTTBD, with a modified optical fiber to realize comprehensive tumor diagnosis and “inside‐out” irradiation in the orthotopic breast tumor, is proposed for the first time. Attributed to the intense donor‐acceptor interaction, highly distorted conformation, abundant molecular rotors, and loose intermolecular packing upon aggregation, tBuTTBD can synchronously undergo second near‐infrared (NIR‐II) fluorescence emission, photothermal and photodynamic generation under laser irradiation, contributing to a trimodal NIR‐II fluorescence‐photoacoustic (PA)‐photothermal imaging‐guided phototherapy. The tumor treatment is further carried out following the insertion of a modified optical fiber, which is fabricated by splicing a flat‐end fiber with an air‐core fiber. This configuration aims to enable effective in situ phototherapy by maximizing energy utilization for therapeutic benefits. This work not only enriches the palette of NIR‐II phototheranostic agents but also provides valuable insight for exploring an integrated phototheranostic protocol for practical cancer treatment.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering Shenzhen University Medical School Shenzhen University Shenzhen Guangdong 518055 China

Center for AIE Research Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. China

Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things Guangdong and Hong Kong Joint Research Centre for Optical Fiber Sensors State Key Laboratory of Radio Frequency Heterogeneous Integration Shenzhen University Shenzhen 518060 China

Shenzhen Key Laboratory of Ultrafast Laser Micro/Nano Manufacturing Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education/Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 China

Research Laboratory for Biomedical Optics and Molecular Imaging Key Laboratory of Biomedical Imaging Science and System Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China

School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen (CUHK‐Shenzhen) Guangdong 518172 China

Funding

National Natural Science Foundation of China · Basic and Applied Basic Research Foundation of Guangdong Province

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