DataVXAdvanced MaterialsPaper
journal article·2023-05

In Situ Transformable Nanoplatforms with Supramolecular Cross‐Linking Triggered Complementary Function for Enhanced Cancer Photodynamic Therapy

Mengyao Zhao, Hongjun Zhuang, Benhao Li, Meiwan Chen, Xiaoyuan Chen

Advanced Materials· Volume 35· Issue 20
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Source abstract

Abstract

Abstract In vivo cross‐linking of nanoparticles is widely used to increase accumulation of therapeutic agents at tumor site for enhanced therapy. However, the components in nanoplatforms usually only play for one role and are independent of each other, unable to amplify their biofunctions. Herein, a complementary functioning tumor microenvironment triggered, supramolecular coordination‐induced nanoparticle cross‐linking strategy is constructed for enhanced photodynamic therapy. Manganese oxide (MnOx) and polyhydroxy photosensitizer hypericin (Hyp) are coated and loaded onto lanthanide‐doped upconversion nanoparticles (UCNPs) to form transformable UCNP@MnOx‐Hyp. In CT26 mouse colon cancer cells and xenograft tumors, UCNP@MnOx‐Hyp is reduced by glutathione and H2O2, releasing Mn2+ and Hyp for in situ cross‐linking to transform to UCNP@Mn2+‐Hyp. Compared to the simple photosensitizer‐loaded UCNP@PEI‐Hyp, the Mn2+‐Hyp coordination redshifts absorbance of Hyp and improves the energy transfer efficiency from UCNPs to Hyp (5.6‐fold). In turn, the supramolecular coordination‐induced UCNPs cross‐linking exhibits enhanced luminescence recovery and increased intracellular accumulation of both UCNPs and Hyp, thus enhancing the photodynamic therapy efficacy both at cellular level (2.1‐fold) and in vivo, realizing the function amplification of each component after responsive transformation and offering a new avenue for enhanced cancer therapy.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Macau 999078 China

Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers and iChem Shanghai Key Laboratory of Molecular Catalysis and Innovative Material Fudan University Shanghai 200433 China

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive, Proteos Singapore 138673 Singapore

Funding

National Natural Science Foundation of China · Science and Technology Development Fund · National Medical Research Council

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