Low‐Temperature Adaptive Single‐Atom Iron Nanozymes against Viruses in the Cold Chain

Tao Qin; Yulian Chen; Xinyu Miao; Mengjuan Shao; Nuo Xu; Chunxiao Mou; Zhenhai Chen; Yuncong Yin; Sujuan Chen; Yinyan Yin; Lizeng Gao; Daxin Peng; Xiufan Liu

doi:10.1002/adma.202309669

journal article·2024-04Open access

Low‐Temperature Adaptive Single‐Atom Iron Nanozymes against Viruses in the Cold Chain

Tao Qin, Yulian Chen, Xinyu Miao, Mengjuan Shao, Nuo Xu, Chunxiao Mou, Zhenhai Chen, Yuncong Yin, Sujuan Chen, Yinyan Yin, Lizeng Gao, Daxin Peng, Xiufan Liu

Advanced Materials· Volume 36· Issue 15

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Source abstract

Abstract

Abstract Outbreaks of viral infectious diseases, such as the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and influenza A virus (IAV), pose a great threat to human health. Viral spread is accelerated worldwide by the development of cold chain logistics; Therefore, an effective antiviral approach is required. In this study, it is aimed to develop a distinct antiviral strategy using nanozymes with low‐temperature adaptability, suitable for cold chain logistics. Phosphorus (P) atoms are added to the remote counter position of Fe‐N‐C center to prepare FeN₄P₂‐single‐atom nanozymes (SAzymes), exhibiting lipid oxidase (OXD)‐like activity at cold chain temperatures (−20, and 4 °C). This feature enables FeN₄P₂‐SAzymes to disrupt multiple enveloped viruses (human, swine, and avian coronaviruses, and H1‐H11 subtypes of IAV) by catalyzing lipid peroxidation of the viral lipid envelope. Under the simulated conditions of cold chain logistics, FeN₄P₂‐SAzymes are successfully applied as antiviral coatings on outer packaging and personal protective equipment; Therefore, FeN₄P₂‐SAzymes with low‐temperature adaptability and broad‐spectrum antiviral properties may serve as key materials for developing specific antiviral approaches to interrupt viral transmission through the cold chain.

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Research context

Nanomaterials Catalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu 225009 P. R. China

Joint International Research Laboratory of Agriculture and Agri‐Product Safety the Ministry of Education of China Yangzhou University Yangzhou Jiangsu 225009 P. R. China

Jiangsu Co‐Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses Yangzhou University Yangzhou Jiangsu 225009 P. R. China

College of Medicine Yangzhou University Yangzhou Jiangsu 225009 P. R. China

International Research Laboratory of Prevention and Control of Important Animal Infectious Diseases and Zoonotic Diseases of Jiangsu Higher Education Institutions Yangzhou University Yangzhou Jiangsu 225009 P. R. China

Guangling College Yangzhou University Yangzhou Jiangsu 225009 P. R. China

CAS Engineering Laboratory for Nanozyme Institute of Biophysics Chinese Academy of Sciences Beijing 100700 P. R. China

Nanozyme Laboratory in Zhongyuan Henan 451163 P. R. China

Jiangsu Research Centre of Engineering and Technology for Prevention and Control of Poultry Disease Yangzhou Jiangsu 225009 P. R. China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Higher Education Discipline Innovation Project

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