DataVXAdvanced MaterialsPaper
journal article·2024-01

Oxygen‐Independent Synchronized ROS Generation and Hypoxia Prodrug Activation with Z‐Scheme Heterostructure Sonosensitizer

Yining Chen, Tianshu Zou, Gaoying Xin, Xin Liu, Yunan Yang, Liqi Wei, Biao Zhang, Pengcheng Yu, Yiping Ren, Yanlin Feng, Rui Chen, Fangfang Cao, Xiaoyuan Chen, Yan Cheng

Advanced Materials· Volume 36· Issue 3
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Source abstract

Abstract

Abstract Combination therapy has emerged as a promising approach for effective tumor treatment. However, the combination of sonodynamic therapy (SDT) and hypoxia‐activated prodrugs (HAPs) has not been explored due to the contradictory requirement of oxygen (O2) for reactive oxygen species (ROS) generation and the necessity to avoid O2 for the activation of HAPs. In this study, this challenge is addressed by developing BiOCl‐Au‐Ag2S Z‐scheme heterostructure nanoparticles loaded with tirapazamine (TPZ) to achieve O2‐independent therapy. These nanoparticles demonstrate efficient electron–hole separation under ultrasound irradiation while maintaining a high redox potential. The generated holes react with water to efficiently produce hydroxyl radicals, while the electrons autonomously activate TPZ, negating the need for O2. In vitro and in vivo assessments validate the effective tumor elimination by these Z‐scheme nanoparticles without disrupting the hypoxic environment. This innovative design overcomes the limitations associated with O2 requirement in SDT and introduces a novel strategy for HAP activation and synergistic therapy between ROS and HAPs‐based therapy.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence Properties of Advanced Materials · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Engineering Research Center of Bioreactor and Pharmaceutical Development Ministry of Education College of Life Science Jilin Agricultural University Changchun 130118 P. R. China

Jilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement College of Science Changchun University Changchun 130022 P. R. China

Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education, and the Department of Physiology Shanxi Medical University Taiyuan 030001 P. R. China

Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Institute of Molecular and Cell Biology Agency for Science, Technology, and Research (A*STAR) 61 Biopolis Drive, Proteos Singapore 138673 Singapore

Funding

National Natural Science Foundation of China · National University of Singapore · National Medical Research Council · National Research Foundation

References (51)

Show source-provided references
1. 10.1016/j.ccr.2021.21408710.1016/j.ccr.2021.214087 ↗
2. 10.1016/j.mattod.2023.03.02510.1016/j.mattod.2023.03.025 ↗
3. 10.1016/j.nantod.2023.10178210.1016/j.nantod.2023.101782 ↗
4. 10.1002/EXP.2021002310.1002/EXP.20210023 ↗
5. 10.1016/j.biomaterials.2023.12212210.1016/j.biomaterials.2023.122122 ↗
6. 10.1016/j.cej.2023.14142710.1016/j.cej.2023.141427 ↗
7. 10.1002/EXP.2022016110.1002/EXP.20220161 ↗
8. 10.1016/j.cclet.2022.10785310.1016/j.cclet.2022.107853 ↗
9. 10.1038/s41467-022-35580-z10.1038/s41467-022-35580-z ↗
10. 10.1002/adma.20221113010.1002/adma.202211130 ↗
11. 10.1021/acsnano.2c1169110.1021/acsnano.2c11691 ↗
12. 10.1016/j.biomaterials.2021.12082210.1016/j.biomaterials.2021.120822 ↗
13. 10.1021/acsami.1c0564410.1021/acsami.1c05644 ↗
14. 10.1002/adma.20210743410.1002/adma.202107434 ↗
15. 10.1016/j.jcis.2022.09.06110.1016/j.jcis.2022.09.061 ↗
16. 10.1016/S1470-2045(04)01529-310.1016/S1470-2045(04)01529-3 ↗
17. 10.1002/adma.20230250810.1002/adma.202302508 ↗
18. 10.1016/j.biomaterials.2022.12177010.1016/j.biomaterials.2022.121770 ↗
19. 10.1002/adma.20211036410.1002/adma.202110364 ↗
20. 10.1002/adma.20210996910.1002/adma.202109969 ↗
21. 10.1002/smll.20210228610.1002/smll.202102286 ↗
22. 10.1039/D0BM01876G10.1039/D0BM01876G ↗
23. 10.1021/nn300934k10.1021/nn300934k ↗
24. 10.1038/s41557-020-00624-810.1038/s41557-020-00624-8 ↗
25. 10.1002/slct.20180272910.1002/slct.201802729 ↗
26. 10.1039/C6SC00389C10.1039/C6SC00389C ↗
27. 10.1039/C5NR05154A10.1039/C5NR05154A ↗
28. 10.1016/j.apcatb.2021.12041310.1016/j.apcatb.2021.120413 ↗
29. Liang S. · Adv. Mater. · 2021 · 33
30. 10.1002/advs.20210574710.1002/advs.202105747 ↗
31. 10.1002/advs.20220034610.1002/advs.202200346 ↗
32. 10.1002/adhm.20200166610.1002/adhm.202001666 ↗
33. 10.1002/adma.20190810910.1002/adma.201908109 ↗
34. 10.1021/acsami.2c1529910.1021/acsami.2c15299 ↗
35. 10.1016/j.chemosphere.2016.05.02110.1016/j.chemosphere.2016.05.021 ↗
36. 10.1016/j.biomaterials.2020.12045110.1016/j.biomaterials.2020.120451 ↗
37. 10.1021/acsomega.0c0627610.1021/acsomega.0c06276 ↗
38. Tada H. · ACS Nano · 2011 · 5 · 782
39. 10.1002/anie.20110450710.1002/anie.201104507 ↗
40. 10.1016/j.jhazmat.2015.10.02910.1016/j.jhazmat.2015.10.029 ↗
41. 10.1002/adom.20140003410.1002/adom.201400034 ↗
42. 10.1039/b823320a10.1039/b823320a ↗
43. 10.1039/c3nj00413a10.1039/c3nj00413a ↗
44. 10.1186/s11671-017-2007-y10.1186/s11671-017-2007-y ↗
45. Anju S. G. · Res. J. Recent Sci. · 2012 · 1 · 191
46. 10.1002/adma.20180722610.1002/adma.201807226 ↗
47. 10.1002/anie.20200092910.1002/anie.202000929 ↗
48. 10.1002/EXP.2021001010.1002/EXP.20210010 ↗
49. 10.1021/ja501699e10.1021/ja501699e ↗
50. 10.1126/science.111439710.1126/science.1114397 ↗
51. 10.1002/adfm.20200807810.1002/adfm.202008078 ↗