journal article·2025-08

AIEgen‐Based Covalent Organic Frameworks for Preventing Malignant Ventricular Arrhythmias Via Local Hyperthermia Therapy

Liang Zhang, Fuding Guo, Saiting Xu, Qiang Deng, Mengjie Xie, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam, Hexiang Deng, Hong Jiang, Lilei Yu, Ben Zhong Tang

Advanced Materials· Volume 37· Issue 31
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Abstract

Abstract The engineering of aggregation‐induced emission luminogens (AIEgen) based covalent organic frameworks (COFs), TDTA‐COF, BTDTA‐COF, and BTDBETA‐COF are reported, as hyperthermia agents for inhibiting the occurrence of malignant ventricular arrhythmias (VAs). These AIE COFs exhibit dual functionality, as they not only directly modulate the function and neural activity of stellate ganglion (SG) through local hyperthermia therapy (LHT) but also induce the browning of white fat and improve the neuroinflammation peri‐SG microenvironment, which is favorable for inhibiting ischemia‐induced VAs. In vivo studies have confirmed that BTDBETA‐COF‐mediated LHT enhances thermogenesis and browning‐related gene expression, thereby serving a synergistic role in combating VAs. Transcriptome analysis of peri‐SG adipose tissue reveals a substantial downregulation of inflammatory cytokines, highlighting the potency of BTDBETA‐COF‐mediated LHT in ameliorating the neuroinflammation peri‐SG microenvironment and offering myocardial and arrhythmia protection. The work on AIE COF‐based hyperthermia agent for VAs inhibition provides a new avenue for mitigating cardiac sympathetic nerve hyperactivity.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Pharmacological Receptor Mechanisms and Effects · Adipose Tissue and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry and The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong 999077 China

Department of Cardiology, Renmin Hospital of Wuhan University Institute of Molecular Medicine, Renmin Hospital of Wuhan University Hubei Key Laboratory of Autonomic Nervous System Modulation Hubei Key Laboratory of Cardiology, Cardiovascular Research Institute, Wuhan University, Cardiac Autonomic Nervous System Research Center of Wuhan University, Taikang Center for Life and Medical Sciences, Wuhan University Wuhan University Jiefang Road Wuhan 430060 China

Institute of Molecular Medicine, Renmin Hospital of Wuhan University Key Laboratory of Biomedical Polymers‐Ministry of Education, College of Chemistry and Molecular Sciences Wuhan University Luojiashan Wuhan 430072 China

Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong Shenzhen Guangdong 518172 China

Center for Aggregation‐Induced Emission South China University of Technology Guangzhou 510640 China

Funding

National Natural Science Foundation of China · Innovation and Technology Commission · China Postdoctoral Science Foundation · National Key Research and Development Program of China

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