journal article·2024-11Open access

Fiber Optic‐Mediated Type I Photodynamic Therapy of Brain Glioblastoma Based on an Aggregation‐Induced Emission Photosensitizer

Wenguang Zhang, Miaomiao Kang, Xue Li, Yinzhen Pan, Zhuorong Li, Yibin Zhang, Changrui Liao, Gaixia Xu, Zhijun Zhang, Ben Zhong Tang, Zhourui Xu, Dong Wang

Advanced Materials· Volume 36· Issue 47

Abstract

Abstract Glioblastoma (GBM) is one of the most lethal human malignancies. The current standard‐of‐care is highly invasive with strong toxic side effects, leading to poor prognosis and high mortality. As a safe and effective clinical approach, photodynamic therapy (PDT) has emerged as a suitable option for GBM. Nevertheless, its implementation is significantly impeded by the limits of light penetration depth and the firm reliance on oxygen. To overcome these challenges, herein, a promising strategy that harnesses a modified optical fiber and less oxygen‐dependent Type I aggregation‐induced emission (AIE) photosensitizer (PS) is developed for the first time to realize in vivo GBM treatments. The proposed AIE PS, namely TTTMN, characterized by a highly twisted molecular architecture and a bulky spacer, exhibits enhanced near‐infrared emission and strong production of hydroxyl and superoxide radicals at the aggregated state, thus affording efficient fluorescence imaging‐guided PDT once formulated into nanoparticles. The inhibition of orthotopic and subcutaneous GBM xenografts provides compelling evidence of the treatment efficacy of Type I PDT irradiated through a tumor‐inserted optical fiber. These findings highlight the substantially improved therapeutic outcomes achieved through fiber optic‐mediated Type I PDT, positioning it as a promising therapeutic modality for GBM.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering Shenzhen University Medical School Shenzhen University Shenzhen Guangdong 518055 P. R. China

Center for AIE Research Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. China

Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things Guangdong and Hong Kong Joint Research Centre for Optical Fiber Sensors State Key Laboratory of Radio Frequency Heterogeneous Integration Shenzhen University Shenzhen 518060 P. R. China

Shenzhen Key Laboratory of Ultrafast Laser Micro/Nano Manufacturing Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education/Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 P. R. China

School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen Guangdong 518172 P. R. China

Funding

National Natural Science Foundation of China · Basic and Applied Basic Research Foundation of Guangdong Province

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