Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface
Source abstract
Abstract
Abstract Nanotechnology‐based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their clinical translation requires a deep understanding of the complex interplay between nanotechnology and MSK biology. Organ‐on‐a‐chip (OoC) systems have emerged as an innovative and versatile microphysiological platform to replicate the dynamics of tissue microenvironment for studying nanotechnology–biology interactions. This review first covers recent advances and applications of MSK OoCs and their ability to mimic the biophysical and biochemical stimuli encountered by MSK tissues. Next, by integrating nanotechnology into MSK OoCs, cellular responses and tissue behaviors may be investigated by precisely controlling and manipulating the nanoscale environment. Analysis of MSK disease mechanisms, particularly bone, joint, and muscle tissue degeneration, and drug screening and development of personalized medicine may be greatly facilitated using MSK OoCs. Finally, future challenges and directions are outlined for the field, including advanced sensing technologies, integration of immune‐active components, and enhancement of biomimetic functionality. By highlighting the emerging applications of MSK OoCs, this review aims to advance the understanding of the intricate nanotechnology–MSK biology interface and its significance in MSK disease management, and the development of innovative and personalized therapeutic and interventional strategies.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Neuroscience and Neural Engineering · Cellular Mechanics and Interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Engineering The Chinese University of Hong Kong NT Hong Kong SAR 999077 P. R. China
Center for Neuromusculoskeletal Restorative Medicine Hong Kong Science Park NT Hong Kong SAR 999077 P. R. China
Department of Orthopaedics and Traumatology The Chinese University of Hong Kong NT Hong Kong SAR 999077 P. R. China
Institute for Tissue Engineering and Regenerative Medicine The Chinese University of Hong Kong NT Hong Kong SAR 999077 P. R. China
School of Biomedical Sciences The Chinese University of Hong Kong NT Hong Kong SAR 999077 P. R. China
The First Affiliated Hospital of Shenzhen University Shenzhen Second People's Hospital Shenzhen Guangdong 518037 P. R. China
Clinical Research Centre Zhujiang Hospital Southern Medical University Guangzhou Guangdong 510260 China
Menzies Institute for Medical Research University of Tasmania Hobart Tasmania 7000 Australia
Key Laboratory of Regenerative Medicine Ministry of Education School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR 999077 P. R. China
Shenzhen Research Institute The Chinese University of Hong Kong Shenzhen 518172 P. R. China
Funding
National Natural Science Foundation of China · Chinese University of Hong Kong · National Key Research and Development Program of China · Innovation and Technology Commission - Hong Kong
References (100+)
Show source-provided references
1. 10.1186/1471-2474-12-26010.1186/1471-2474-12-260 ↗
2. 10.1016/S0140-6736(20)32340-010.1016/S0140-6736(20)32340-0 ↗
3. 2020
4. 10.1007/978-94-007-0753-5_189310.1007/978-94-007-0753-5_1893 ↗
5. 10.1038/s41413-020-00105-110.1038/s41413-020-00105-1 ↗
6. 10.1002/anbr.20220008510.1002/anbr.202200085 ↗
7. 10.1186/ar417410.1186/ar4174 ↗
8. 10.1038/s41413-021-00139-z10.1038/s41413-021-00139-z ↗
9. 10.1002/adma.20180404110.1002/adma.201804041 ↗
10. 10.1021/acsnano.9b0048910.1021/acsnano.9b00489 ↗
11. 10.1002/adma.20200880910.1002/adma.202008809 ↗
12. 10.1038/s41467-023-36461-910.1038/s41467-023-36461-9 ↗
13. 10.1021/acsnano.1c1158910.1021/acsnano.1c11589 ↗
14. 10.1002/adma.20170561110.1002/adma.201705611 ↗
15. MA. Secretariat, Ont. Health Technol. Assess. Ser. · 2006 · 6 · 1
16. 10.2147/IJN.S4533210.2147/IJN.S45332 ↗
17. 10.1038/s41413-021-00180-y10.1038/s41413-021-00180-y ↗
18. 10.1038/s41536-023-00289-010.1038/s41536-023-00289-0 ↗
19. 10.1016/j.actbio.2019.01.04310.1016/j.actbio.2019.01.043 ↗
20. 10.1038/boneres.2015.2910.1038/boneres.2015.29 ↗
21. 10.1002/adma.20170566810.1002/adma.201705668 ↗
22. 10.1016/j.jconrel.2019.09.01510.1016/j.jconrel.2019.09.015 ↗
23. 10.1002/adma.20200339910.1002/adma.202003399 ↗
24. 10.1007/s11926-020-0884-z10.1007/s11926-020-0884-z ↗
25. 10.1021/acsnano.2c0867510.1021/acsnano.2c08675 ↗
26. 10.1038/s41578-023-00581-x10.1038/s41578-023-00581-x ↗
27. 10.1038/s41551-018-0314-y10.1038/s41551-018-0314-y ↗
28. 10.1186/s13287-022-03130-510.1186/s13287-022-03130-5 ↗
29. 10.1016/j.tibtech.2022.07.01110.1016/j.tibtech.2022.07.011 ↗
30. 10.1016/j.bioactmat.2020.09.02210.1016/j.bioactmat.2020.09.022 ↗
31. 10.1016/j.stem.2018.02.01110.1016/j.stem.2018.02.011 ↗
32. 10.1038/s41578-018-0034-710.1038/s41578-018-0034-7 ↗
33. 10.3389/fbioe.2019.0016810.3389/fbioe.2019.00168 ↗
34. 10.1002/adfm.20210519010.1002/adfm.202105190 ↗
35. 10.1039/c2lc40611j10.1039/c2lc40611j ↗
36. 10.1021/acsnano.1c0214710.1021/acsnano.1c02147 ↗
37. 10.1002/smll.20200351710.1002/smll.202003517 ↗
38. 10.1186/s40580-021-00253-y10.1186/s40580-021-00253-y ↗
39. 10.1186/s40580-021-00270-x10.1186/s40580-021-00270-x ↗
40. 10.1039/D3NR01661G10.1039/D3NR01661G ↗
41. 10.1186/s40580-021-00261-y10.1186/s40580-021-00261-y ↗
42. 10.1002/admt.20200072610.1002/admt.202000726 ↗
43. 10.1126/sciadv.aaw131710.1126/sciadv.aaw1317 ↗
44. 10.1126/science.118830210.1126/science.1188302 ↗
45. 10.1002/adma.20220885210.1002/adma.202208852 ↗
46. 10.1002/adma.20210564510.1002/adma.202105645 ↗
47. 10.1002/adma.20210875710.1002/adma.202108757 ↗
48. 10.1002/adma.20210842710.1002/adma.202108427 ↗
49. Feng X. · Curr. Chem. Biol. · 2009 · 3 · 189
50. 10.1038/s41413-022-00219-810.1038/s41413-022-00219-8 ↗
51. 10.1177/194173810935043810.1177/1941738109350438 ↗
52. 10.1002/adem.20220030410.1002/adem.202200304 ↗
53. 10.2174/187431290110501010010.2174/1874312901105010100 ↗
54. 10.1136/ard.62.4.30310.1136/ard.62.4.303 ↗
55. 10.1172/JCI20052226310.1172/JCI200522263 ↗
56. 10.1038/nrrheum.2017.11510.1038/nrrheum.2017.115 ↗
57. 10.1038/s41584-021-00736-610.1038/s41584-021-00736-6 ↗
58. 10.1088/1758-5090/ac876710.1088/1758-5090/ac8767 ↗
59. 10.1038/s41413-022-00190-410.1038/s41413-022-00190-4 ↗
60. 10.1001/jama.2023.1967510.1001/jama.2023.19675 ↗
61. 10.1016/S0749-8063(85)80080-310.1016/S0749-8063(85)80080-3 ↗
62. 10.1016/j.bioactmat.2023.01.02510.1016/j.bioactmat.2023.01.025 ↗
63. 10.1093/ptj/81.11.181010.1093/ptj/81.11.1810 ↗
64. Dave H. D. · 2023
65. 10.1038/s41467-023-43402-z10.1038/s41467-023-43402-z ↗
66. 10.1016/j.cmet.2014.12.02110.1016/j.cmet.2014.12.021 ↗
67. 10.3389/fphys.2020.0025310.3389/fphys.2020.00253 ↗
68. 10.1002/jbmr.319910.1002/jbmr.3199 ↗
69. 10.1038/s41584-019-0364-x10.1038/s41584-019-0364-x ↗
70. 10.1002/jor.2281810.1002/jor.22818 ↗
71. 10.1034/j.1600-0838.2000.010006312.x10.1034/j.1600-0838.2000.010006312.x ↗
72. 10.1038/s41584-022-00790-810.1038/s41584-022-00790-8 ↗
73. 10.1007/s40520-021-01817-y10.1007/s40520-021-01817-y ↗
74. 10.1016/j.jocd.2014.08.00110.1016/j.jocd.2014.08.001 ↗
75. 10.1038/nrendo.2015.13810.1038/nrendo.2015.138 ↗
76. 10.3389/fgene.2023.113118210.3389/fgene.2023.1131182 ↗
77. 10.3389/fcell.2022.93206510.3389/fcell.2022.932065 ↗
78. 10.1016/j.ajpath.2020.02.00710.1016/j.ajpath.2020.02.007 ↗
79. 10.1093/cid/ciz07710.1093/cid/ciz077 ↗
80. 10.3389/fcimb.2015.0008510.3389/fcimb.2015.00085 ↗
81. 10.3389/fphar.2017.0015010.3389/fphar.2017.00150 ↗
82. 10.1038/s41572-020-00216-310.1038/s41572-020-00216-3 ↗
83. 10.1038/s41413-023-00249-w10.1038/s41413-023-00249-w ↗
84. 10.1111/iwj.1223110.1111/iwj.12231 ↗
85. 10.1038/s42003-023-04652-110.1038/s42003-023-04652-1 ↗
86. 10.3389/fbioe.2021.66335710.3389/fbioe.2021.663357 ↗
87. 10.1007/s00198-013-2530-310.1007/s00198-013-2530-3 ↗
88. 10.1038/ncprheum072710.1038/ncprheum0727 ↗
89. Roach H. I. · 2007 · 1
90. 10.1016/j.jht.2011.11.00110.1016/j.jht.2011.11.001 ↗
91. 10.1007/978-1-910315-16-3_410.1007/978-1-910315-16-3_4 ↗
92. 10.1093/rheumatology/kes11310.1093/rheumatology/kes113 ↗
93. 10.1186/ar452610.1186/ar4526 ↗
94. 10.3390/biology908019410.3390/biology9080194 ↗
95. 10.1038/nrrheum.2013.9210.1038/nrrheum.2013.92 ↗
96. 10.2165/00002512-199813030-0000610.2165/00002512-199813030-00006 ↗
97. 10.1007/s10974-019-09520-210.1007/s10974-019-09520-2 ↗
98. 10.1016/j.ejr.2021.12.00610.1016/j.ejr.2021.12.006 ↗
99. 10.1007/s10067-012-2143-910.1007/s10067-012-2143-9 ↗
100. 10.1002/jcb.2774110.1002/jcb.27741 ↗