Advancing Scaffold‐Assisted Modality for In Situ Osteochondral Regeneration: A Shift From Biodegradable to Bioadaptable
Source abstract
Abstract
Abstract Over the decades, the management of osteochondral lesions remains a significant yet unmet medical challenge without curative solutions to date. Owing to the complex nature of osteochondral units with multi‐tissues and multicellularity, and inherently divergent cellular turnover capacities, current clinical practices often fall short of robust and satisfactory repair efficacy. Alternative strategies, particularly tissue engineering assisted with biomaterial scaffolds, achieve considerable advances, with the emerging pursuit of a more cost‐effective approach of in situ osteochondral regeneration, as evolving toward cell‐free modalities. By leveraging endogenous cell sources and innate regenerative potential facilitated with instructive scaffolds, promising results are anticipated and being evidenced. Accordingly, a paradigm shift is occurring in scaffold development, from biodegradable and biocompatible to bioadaptable in spatiotemporal control. Hence, this review summarizes the ongoing progress in deploying bioadaptable criteria for scaffold‐based engineering in endogenous osteochondral repair, with emphases on precise control over the scaffolding material, degradation, structure and biomechanics, and surface and biointerfacial characteristics, alongside their distinguished impact on the outcomes. Future outlooks of a highlight on advanced, frontier materials, technologies, and tools tailoring precision medicine and smart healthcare are provided, which potentially paves the path toward the ultimate goal of complete osteochondral regeneration with function restoration.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · Bone and Dental Protein Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Engineering Research Center of Light Alloy Net Forming & State Key Laboratory of Metal Matrix Composite & Center of Hydrogen Science School of Materials Science & Engineering Shanghai Jiao Tong University Shanghai 200240 China
Interdisciplinary Research Center of Biology & Catalysis School of Life Sciences Northwestern Polytechnical University Xi'an 710072 China
Research Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced Technology Chinese Academy of Science Shenzhen Guangdong 518055 China
Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200233 China
Key Laboratory of Biomedical Engineering of Ministry of Education Zhejiang Provincial Key Laboratory of Cardio‐Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China
School of Materials Science and Engineering Peking University Beijing 100871 China
Institute of Medical Robotics & National Engineering Research Center for Advanced Magnetic Resonance Technologies for Diagnosis and Therapy Shanghai Jiao Tong University Shanghai 200240 China
Funding
National Key Research and Development Program of China · National Natural Science Foundation of China · Science and Technology Commission of Shanghai Municipality
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